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Oncaspar · 4.8 · 9 Metabolism and nutrition disorders An alteration in serum lipid levels was observed and changes in serum lip
Eintrag öffnenOncaspar · 4.8 · A rapid weight gain, fluid retention with ascites, hepatomegaly, associated with rapid increase of serum bilir
Eintrag öffnenOncaspar · 4.8 · Blood and lymphatic system disorders Oncaspar can cause mild to moderate myelosuppression, and all three blood
Eintrag öffnenOncaspar · 4.8 · Description of selected adverse reactions The following adverse reactions have been observed in association wi
Eintrag öffnenOncaspar · 4.8 · Endocrine disorders Alterations in endocrine pancreatic function are observed commonly and are expressed mainl
Eintrag öffnenOncaspar · 4.8 · Fatty liver can be observed very frequently. There have been rare reports of cholestasis, icterus, hepatic cel
Eintrag öffnenOncaspar · 4.8 · Gastrointestinal disorders About half of patients develop mild to moderate gastrointestinal reactions such as
Eintrag öffnenOncaspar · 4.8 · General disorders and administration site conditions Pyrexia can occur after the injection, which usually subs
Eintrag öffnenOncaspar · 4.8 · Haemorrhagic or necrotising pancreatitis occurs rarely. One case of pancreatitis with simultaneous acute parot
Eintrag öffnenOncaspar · 4.8 · Hepatobiliary disorders Alteration of liver parameters is common. A dose-independent rise in serum transaminas
Eintrag öffnenOncaspar · 4.8 · Hypersensitivity reactions to Oncaspar, including life-threatening anaphylaxis, angioedema, lip swelling, eye
Eintrag öffnenOncaspar · 4.8 · Immune system disorders Specific antibodies to pegaspargase have been detected; uncommonly they were associate
Eintrag öffnenOncaspar · 4.8 · Impaired protein synthesis can lead to a decline in the serum proteins. There is a dose-independent decrease i
Eintrag öffnenOncaspar · 4.8 · Nervous system disorders Oncaspar may cause central nervous system dysfunctions manifesting as convulsions, an
Eintrag öffnenOncaspar · 4.8 · Not known: Blood urea increased, anti-pegaspargase antibodies, platelet count decreased, hyperammonaemia
Eintrag öffnenOncaspar · 4.8 · Renal and urinary disorders Acute renal failure may develop in rare cases during treatment with L-asparaginase
Eintrag öffnenOncaspar · 4.8 · Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medi
Eintrag öffnenOncaspar · 4.8 · Skin and subcutaneous tissue disorders Allergic reactions can manifest on the skin. One case of toxic epiderma
Eintrag öffnenOncaspar · 4.8 · Summary of the safety profile The adverse reactions described in this section are derived from clinical studie
Eintrag öffnenOncaspar · 4.8 · Table 1: Adverse reactions reported with Oncaspar therapy MedDRA standard system organ Adverse reaction class
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