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Perjeta · 4.8 · Elderly Patients
Eintrag öffnenPerjeta · 4.8 · Hypersensitivity reactions/anaphylaxis In the pivotal trial CLEOPATRA in metastatic breast cancer, the overall
Eintrag öffnenPerjeta · 4.8 · In APHINITY, the incidence of symptomatic heart failure (NYHA class III or IV) with a LVEF decline of at least
Eintrag öffnenPerjeta · 4.8 · In neoadjuvant and adjuvant trials, Perjeta was administered on the same day as other study treatments in all
Eintrag öffnenPerjeta · 4.8 · In the APHINITY trial, a higher incidence of diarrhoea was reported in the Perjeta-treated arm (71.2%) compare
Eintrag öffnenPerjeta · 4.8 · In the APHINITY trial, febrile neutropenia occurred in 12.1% of Perjeta-treated patients and 11.1% of placebo-
Eintrag öffnenPerjeta · 4.8 · In the APHINITY trial, the adverse event of rash occurred in 25.8% of patients in Perjeta arm vs. 20.3% of pat
Eintrag öffnenPerjeta · 4.8 · In the APHINITY trial, the incidence of NCI-CTCAE v.4 Grade 3-4 neutropenia was 40.6% in patients treated with
Eintrag öffnenPerjeta · 4.8 · In the NEOSPHERE trial, 8.4% of patients treated with neoadjuvant Perjeta, trastuzumab and docetaxel experienc
Eintrag öffnenPerjeta · 4.8 · In the NEOSPHERE trial, diarrhoea occurred in 45.8% of patients treated with neoadjuvant Perjeta, trastuzumab
Eintrag öffnenPerjeta · 4.8 · In the NEOSPHERE trial, rash occurred in 40.2% of patients treated with neoadjuvant Perjeta, trastuzumab and d
Eintrag öffnenPerjeta · 4.8 · In the NEOSPHERE trial, the incidence of NCI-CTCAE v.3 Grade 3-4 neutropenia was 74.5% in patients treated wit
Eintrag öffnenPerjeta · 4.8 · In the neoadjuvant and adjuvant trials, hypersensitivity/anaphylaxis events were consistent with those observe
Eintrag öffnenPerjeta · 4.8 · In the neoadjuvant period of the BERENICE trial, the incidence of NYHA Class III/IV symptomatic LVD (congestiv
Eintrag öffnenPerjeta · 4.8 · In the neoadjuvant trial NEOSPHERE, in which patients received 4 cycles of Perjeta as neoadjuvant treatment, t
Eintrag öffnenPerjeta · 4.8 · Infections and infestations Nasopharyngitis Paronychia Upper respiratory tract infection
Eintrag öffnenPerjeta · 4.8 · Infusion-related reactions (IRRs) An infusion-related reaction was defined in the pivotal trials as any event
Eintrag öffnenPerjeta · 4.8 · Laboratory abnormalities In the pivotal trial CLEOPATRA in metastatic breast cancer, the incidence of NCI-CTCA
Eintrag öffnenPerjeta · 4.8 · Left ventricular dysfunction (LVD) In the pivotal trial CLEOPATRA in metastatic breast cancer, the incidence o
Eintrag öffnenPerjeta · 4.8 · Overall, the majority of hypersensitivity reactions were mild or moderate in severity and resolved upon treatm
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