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Pyrukynd · 4.5 · Effect of mitapivat on other medicinal products
Eintrag öffnenPyrukynd · 4.5 · Effects of other medicinal products on mitapivat
Eintrag öffnenPyrukynd · 4.5 · Effects of other medicinal products on mitapivat
Eintrag öffnenPyrukynd · 4.5 · Gastric acid-reducing agents Concomitant use of mitapivat with medicinal products that elevate gastric pH was
Eintrag öffnenPyrukynd · 4.5 · Gastric acid-reducing agents Mitapivat exhibits pH-dependent solubility (see section 5.2) and coadministration
Eintrag öffnenPyrukynd · 4.5 · Hormonal contraceptives Mitapivat may alter the systemic exposure of hormonal contraceptives that are sensitiv
Eintrag öffnenPyrukynd · 4.5 · Hormonal contraceptives Mitapivat may alter the systemic exposure of hormonal contraceptives that are sensitiv
Eintrag öffnenPyrukynd · 4.5 · Mitapivat is primarily metabolised by CYP3A4 and is a substrate for P-glycoprotein (P-gp). Mitapivat induces C
Eintrag öffnenPyrukynd · 4.5 · Mitapivat is primarily metabolised by CYP3A4 and is a substrate for P-glycoprotein (P-gp). Mitapivat induces C
Eintrag öffnenPyrukynd · 4.5 · P-gp substrates Based on in vitro data, mitapivat may induce and inhibit P-gp (see section 5.2) and may alter
Eintrag öffnenPyrukynd · 4.5 · P-gp substrates Based on in vitro data, mitapivat may induce and inhibit P-gp (see section 5.2) and may alter
Eintrag öffnenPyrukynd · 4.5 · UGT1A1, CYP2B6 and CYP2C substrates Based on in vitro data, mitapivat may induce UGT1A1, CYP2B6, CYP2C8, CYP2C
Eintrag öffnenPyrukynd · 4.5 · UGT1A1, CYP2B6 and CYP2C substrates Based on in vitro data, mitapivat may induce UGT1A1, CYP2B6, CYP2C8, CYP2C
Eintrag öffnenPyrukynd · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenPyrukynd · 4.6 Fertility, pregnancy and lactation · 2
Eintrag öffnenPyrukynd · 4.8 Undesirable effects · 1
Eintrag öffnenPyrukynd · 4.8 Undesirable effects · 2
Eintrag öffnenPyrukynd · 4.8 · 23 Tabulated list of adverse reactions
Eintrag öffnenPyrukynd · 4.8 · 24 hormone levels expected throughout the normal menstrual cycle and the various types of hormonal contracepti
Eintrag öffnenPyrukynd · 4.8 · 7 (ACTIVATE) and a single-arm clinical study of adult patients with PK deficiency who were regularly transfuse
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