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Sildenafil ratiopharm · 4.5 · Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in pl
Eintrag öffnenSildenafil ratiopharm · 4.5 · In healthy male volunteers, sildenafil at steady state (80 mg t.i.d.) resulted in a 49.8% increase in bosentan
Eintrag öffnenSildenafil ratiopharm · 4.5 · In vitro studies Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3
Eintrag öffnenSildenafil ratiopharm · 4.5 · In vitro studies Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (majo
Eintrag öffnenSildenafil ratiopharm · 4.5 · In vivo studies Consistent with its known effects on the nitric oxide/cGMP pathway (see section 5.1), sildenaf
Eintrag öffnenSildenafil ratiopharm · 4.5 · In vivo studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil
Eintrag öffnenSildenafil ratiopharm · 4.5 · Nicorandil is a hybrid of potassium channel activator and nitrate. Due to the nitrate component it has the pot
Eintrag öffnenSildenafil ratiopharm · 4.5 · No significant interactions were shown when sildenafil (50 mg) was co-administered with tolbutamide (250 mg) o
Eintrag öffnenSildenafil ratiopharm · 4.5 · Pooling of the following classes of antihypertensive medication, diuretics, beta-blockers, ACE inhibitors, ang
Eintrag öffnenSildenafil ratiopharm · 4.5 · Riociguat: Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors we
Eintrag öffnenSildenafil ratiopharm · 4.5 · Sildenafil (100 mg) did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavi
Eintrag öffnenSildenafil ratiopharm · 4.5 · Sildenafil (50 mg) did not potentiate the hypotensive effects of alcohol in healthy volunteers with mean maxim
Eintrag öffnenSildenafil ratiopharm · 4.5 · Sildenafil (50 mg) did not potentiate the increase in bleeding time caused by acetyl salicylic acid (150 mg).
Eintrag öffnenSildenafil ratiopharm · 4.5 · Single doses of antacid (magnesium hydroxide/aluminium hydroxide) did not affect the bioavailability of silden
Eintrag öffnenSildenafil ratiopharm · 4.5 · There are no data on the interaction of sildenafil and non-specific phosphodiesterase inhibitors such as theop
Eintrag öffnenSildenafil ratiopharm · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenSildenafil ratiopharm · 4.8 Undesirable effects · 1
Eintrag öffnenSildenafil ratiopharm · 4.8 · *Reported during post-marketing surveillance only **Visual colour distortions: Chloropsia, Chromatopsia, Cyano
Eintrag öffnenSildenafil ratiopharm · 4.8 · 8 System Organ Very Common Uncommon Rare Class common (≥ 1/100 and (≥ 1/1,000 and (≥ 1/10,000 and (≥ 1/10) < 1
Eintrag öffnenSildenafil ratiopharm · 4.8 · 9 System Organ Very Common Uncommon Rare Class common (≥ 1/100 and (≥ 1/1,000 and (≥ 1/10,000 and (≥ 1/10) < 1
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