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Spectrila · 4.8 Undesirable effects · 1
Eintrag öffnenSpectrila · 4.8 · *Including all allergic reactions within 12 hours after asparaginase infusion and all adverse events with CTCA
Eintrag öffnenSpectrila · 4.8 · 10 A comparable proportion of patients in both groups developed anti-asparaginase antibodies before the start
Eintrag öffnenSpectrila · 4.8 · 11 Adults and other special populations
Eintrag öffnenSpectrila · 4.8 · 8 Rare Anaphylactic shock Endocrine disorders Very rare Secondary hypothyroidism, hypoparathyroidism Metabolis
Eintrag öffnenSpectrila · 4.8 · 9 Investigations Very common Increase in transaminases, blood bilirubin, blood alkaline phosphatase, blood cho
Eintrag öffnenSpectrila · 4.8 · Because of a higher frequency of comorbidities such as liver and/or renal impairment, patients > 55 years of a
Eintrag öffnenSpectrila · 4.8 · Common Acute pancreatitis
Eintrag öffnenSpectrila · 4.8 · Common Hypersensitivity including bronchospasm
Eintrag öffnenSpectrila · 4.8 · Common Hypoglycaemia, decreased appetite, weight loss
Eintrag öffnenSpectrila · 4.8 · Common Increase in amylase, lipase, abnormal electroencephalogram (EEG) (reduced alpha wave activity, increase
Eintrag öffnenSpectrila · 4.8 · Common Pain (back pain, joint pain)
Eintrag öffnenSpectrila · 4.8 · Data on safety of Spectrila in infants < 1 year of age is limited.
Eintrag öffnenSpectrila · 4.8 · Description of selected adverse reactions
Eintrag öffnenSpectrila · 4.8 · Dyslipidemia Mild to moderate changes in blood lipid values (e.g. increased or decreased cholesterol, increase
Eintrag öffnenSpectrila · 4.8 · Frequencies in this table are defined using the following convention: Very common (≥1/10); common (≥1/100 to <
Eintrag öffnenSpectrila · 4.8 · Gastrointestinal disorders Nausea/vomiting are very commonly observed in patients treated with asparaginase-co
Eintrag öffnenSpectrila · 4.8 · Hyperammonaemia Hyperammonaemia has been reported uncommonly in patients treated with asparaginase-containing
Eintrag öffnenSpectrila · 4.8 · Hyperglycaemia and hypoglycaemia Changes in endocrine pancreatic function are observed very commonly during tr
Eintrag öffnenSpectrila · 4.8 · Hypoalbuminaemia As a result of impaired protein synthesis, the serum protein level (especially albumin) decre
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