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Tagrisso · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenTagrisso · 4.8 Undesirable effects · 1
Eintrag öffnenTagrisso · 4.8 · 10 Table 2. Adverse reactions reported in ADAURA, LAURA, FLAURA, FLAURA2 and AURA studies
Eintrag öffnenTagrisso · 4.8 · 11 MedDRA SOC TAGRISSO with pemetrexed and TAGRISSOa and MedDRA platinum-based chemotherapyb term CIOMS descri
Eintrag öffnenTagrisso · 4.8 · 12 m Includes: acne, dermatitis, dermatitis acneiform, drug eruption, erythema, folliculitis, pustule, rash, r
Eintrag öffnenTagrisso · 4.8 · 13 msec, and 4% of patients (n=79) had an increase from baseline QTc greater than 60 msec. A pharmacokinetic/
Eintrag öffnenTagrisso · 4.8 · 14 Reporting of suspected adverse reactions
Eintrag öffnenTagrisso · 4.8 · Adverse reactions are listed according to system organ class (SOC) in MedDRA. Within each system organ class,
Eintrag öffnenTagrisso · 4.8 · Adverse reactions have been assigned to the frequency categories in Table 2 where possible based on the incide
Eintrag öffnenTagrisso · 4.8 · Cardiac disorders
Eintrag öffnenTagrisso · 4.8 · Cardiac failure Uncommon (0.5%) 0.2% Common (1.8%) 1.1%f
Eintrag öffnenTagrisso · 4.8 · Description of selected adverse reactions
Eintrag öffnenTagrisso · 4.8 · Early reductions in the median laboratory counts of leukocytes, lymphocytes, neutrophils and platelets have be
Eintrag öffnenTagrisso · 4.8 · Eye disorders Keratitise Uncommon (0.6%) 0.05% Uncommon (0.7%) 0%
Eintrag öffnenTagrisso · 4.8 · Gastrointestinal effects
Eintrag öffnenTagrisso · 4.8 · Haematological events
Eintrag öffnenTagrisso · 4.8 · ILD or ILD-like adverse reactions were reported in 3.3% and were fatal in 0.4% (n=1) of the 276 patients who r
Eintrag öffnenTagrisso · 4.8 · ILD or ILD-like adverse reactions were reported in 7.7% and were fatal in 0.7% (n=1) of the 143 patients who r
Eintrag öffnenTagrisso · 4.8 · In ADAURA, FLAURA, FLAURA2, LAURA and AURA3 (TAGRISSO monotherapy; N=1956), 43% of patients were 65 years of a
Eintrag öffnenTagrisso · 4.8 · In the ADAURA, FLAURA, FLAURA2 (monotherapy arm), AURA and LAURA studies, ILD or ILD-like adverse reactions we
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