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Tracleer · 4.5 · After co-administration of bosentan for 9.5 days, the plasma exposures to lopinavir and ritonavir decreased to
Eintrag öffnenTracleer · 4.5 · Bosentan is an inducer of the cytochrome P450 (CYP) isoenzymes CYP2C9 and CYP3A4. In vitro data also suggest a
Eintrag öffnenTracleer · 4.5 · Bosentan is an inducer of the cytochrome P450 (CYP) isoenzymes CYP2C9 and CYP3A4. In vitro data also suggest a
Eintrag öffnenTracleer · 4.5 · Bosentan is metabolised by CYP2C9 and CYP3A4. Inhibition of these isoenzymes may increase the plasma concentra
Eintrag öffnenTracleer · 4.5 · Bosentan is metabolised by CYP2C9 and CYP3A4. Inhibition of these isoenzymes may increase the plasma concentra
Eintrag öffnenTracleer · 4.5 · Cyclosporine A: Co-administration of Tracleer and cyclosporine A (a calcineurin inhibitor) is contraindicated
Eintrag öffnenTracleer · 4.5 · Cyclosporine A: Co-administration of Tracleer and cyclosporine A (a calcineurin inhibitor) is contraindicated
Eintrag öffnenTracleer · 4.5 · Digoxin: Co-administration for 7 days of bosentan 500 mg twice daily with digoxin decreased the AUC, Cmax and
Eintrag öffnenTracleer · 4.5 · Digoxin: Co-administration for 7 days of bosentan 500 mg twice daily with digoxin decreased the AUC, Cmax and
Eintrag öffnenTracleer · 4.5 · Epoprostenol: Limited data obtained from a study (AC-052-356 [BREATHE-3]) in which 10 paediatric patients rece
Eintrag öffnenTracleer · 4.5 · Epoprostenol: Limited data obtained from a study (AC-052-356 [BREATHE-3]) in which 10 paediatric patients rece
Eintrag öffnenTracleer · 4.5 · Fluconazole and other inhibitors of both CYP2C9 and CYP3A4: Co-administration with fluconazole, which inhibits
Eintrag öffnenTracleer · 4.5 · Fluconazole and other inhibitors of both CYP2C9 and CYP3A4: Co-administration with fluconazole, which inhibits
Eintrag öffnenTracleer · 4.5 · Glibenclamide: Co-administration of bosentan 125 mg twice daily for 5 days decreased the plasma concentrations
Eintrag öffnenTracleer · 4.5 · Glibenclamide: Co-administration of bosentan 125 mg twice daily for 5 days decreased the plasma concentrations
Eintrag öffnenTracleer · 4.5 · Hormonal contraceptives: Co-administration of bosentan 125 mg twice daily for 7 days with a single dose of ora
Eintrag öffnenTracleer · 4.5 · Hormonal contraceptives: Co-administration of bosentan 125 mg twice daily for 7 days with a single dose of ora
Eintrag öffnenTracleer · 4.5 · Interaction studies have only been performed in adults.
Eintrag öffnenTracleer · 4.5 · Interaction studies have only been performed in adults.
Eintrag öffnenTracleer · 4.5 · Ketoconazole: Co-administration for 6 days of bosentan 62.5 mg twice daily with ketoconazole, a potent CYP3A4
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