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Trajenta · 4.5 · Warfarin: multiple daily doses of 5 mg linagliptin did not alter the pharmacokinetics of S(-) or R(+) warfarin
Eintrag öffnenTrajenta · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenTrajenta · 4.8 Undesirable effects · 1
Eintrag öffnenTrajenta · 4.8 · - monotherapy with short-term duration of up to 4 weeks - monotherapy with ≥ 12 week duration - add-on to metf
Eintrag öffnenTrajenta · 4.8 · 5 The adverse reactions are listed by absolute frequency. Frequencies are defined as very common (≥ 1/10), com
Eintrag öffnenTrajenta · 4.8 · 6 Paediatric population Overall, in clinical trials in paediatric patients with type 2 diabetes mellitus aged
Eintrag öffnenTrajenta · 4.8 · Adverse reactions classified by system organ class and MedDRA preferred terms reported in patients who receive
Eintrag öffnenTrajenta · 4.8 · In the CARMELINA study, bullous pemphigoid was reported in 0.2% of patients treated with linagliptin and in no
Eintrag öffnenTrajenta · 4.8 · In the overall study observation period adjudicated acute pancreatitis was reported in 0.3% of patients treate
Eintrag öffnenTrajenta · 4.8 · In the placebo-controlled studies 4.9% of patients experienced “hypoglycaemia” as an adverse reaction under li
Eintrag öffnenTrajenta · 4.8 · In the treated population, severe hypoglycaemic events (requiring assistance) were reported in 3.0% of patient
Eintrag öffnenTrajenta · 4.8 · Linagliptin cardiovascular and renal safety study (CARMELINA) The CARMELINA study evaluated the cardiovascular
Eintrag öffnenTrajenta · 4.8 · Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medi
Eintrag öffnenTrajenta · 4.8 · Summary of the safety profile In the pooled analysis of the placebo-controlled trials, the overall incidence o
Eintrag öffnenTrajenta · 4.8 · System organ class Frequency of adverse reaction Adverse reaction Infections and infestations Nasopharyngitis
Eintrag öffnenTrajenta · 4.8 · Table 1 Adverse reactions reported in patients who received linagliptin 5 mg daily as monotherapy or as add-on
Eintrag öffnenTrajenta · 4.8 · Tabulated list of adverse reactions Due to the impact of the background therapy on adverse reactions (e.g. on
Eintrag öffnenTrajenta · 4.8 · The most frequently reported adverse reaction was “hypoglycaemia” observed under the triple combination, linag
Eintrag öffnenTrajenta · 4.8 · The placebo-controlled studies included studies where linagliptin was given as
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