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Triumeq · 4.5 · 44 Effect of other medicinal products on the pharmacokinetics of dolutegravir, abacavir and lamivudine
Eintrag öffnenTriumeq · 4.5 · 46 expected, due to likely similar to or less than that of induction) efavirenz. The recommended dose of dolut
Eintrag öffnenTriumeq · 4.5 · 47 Cmax ↓ 24% on limited data, did not result in Cτ ↓ 49% decreased efficacy in Phase III studies. No dose adj
Eintrag öffnenTriumeq · 4.5 · 48 Rifabutin Dolutegravir ↔ No dose adjustment is necessary. AUC ↓ 5% Cmax ↑ 16% Cτ ↓ 30% (induction of UGT1A1
Eintrag öffnenTriumeq · 4.5 · 49 Retinoids Retinoid compounds Interaction not studied Insufficient data to recommend dose (e.g. Isotretinoin
Eintrag öffnenTriumeq · 4.5 · 50 (Complex binding to The stated reductions in dolutegravir polyvalent ions) exposure were observed with the
Eintrag öffnenTriumeq · 4.5 · 7 transporters may decrease dolutegravir plasma concentration and reduce the therapeutic effect of dolutegravi
Eintrag öffnenTriumeq · 4.5 · 8 at end of dosing interval as “Cτ”). The table should not be considered exhaustive but is representative of t
Eintrag öffnenTriumeq · 4.5 · 9 expected, due to nevirapine on dolutegravir exposure is induction) likely similar to or less than that of ef
Eintrag öffnenTriumeq · 4.5 · Abacavir is metabolised by UGT (UGT2B7) and alcohol dehydrogenase; co-administration of inducers (e.g. rifampi
Eintrag öffnenTriumeq · 4.5 · Abacavir is metabolised by UGT (UGT2B7) and alcohol dehydrogenase; co-administration of inducers (e.g. rifampi
Eintrag öffnenTriumeq · 4.5 · Although abacavir and lamivudine are substrates of BCRP and P-gp in vitro, given the high absolute bioavailabi
Eintrag öffnenTriumeq · 4.5 · Although abacavir and lamivudine are substrates of BCRP and P-gp in vitro, given the high absolute bioavailabi
Eintrag öffnenTriumeq · 4.5 · Atazanavir ↔ (historical controls) (inhibition of UGT1A1 and CYP3A enzymes) Atazanavir+ ritonavir/ Dolutegravi
Eintrag öffnenTriumeq · 4.5 · Atazanavir ↔ (historical controls) (inhibition of UGT1A1 and CYP3A enzymes) Atazanavir+ ritonavir/ Dolutegravi
Eintrag öffnenTriumeq · 4.5 · Atazanavir ↔ Ritonavir ↔ Tipranavir+ritonavir/ Dolutegravir ↓ The recommended dose of dolutegravir Dolutegravi
Eintrag öffnenTriumeq · 4.5 · Atazanavir ↔ Ritonavir ↔ Tipranavir+ritonavir/ Dolutegravir ↓ The recommended dose of dolutegravir Dolutegravi
Eintrag öffnenTriumeq · 4.5 · Clinically significant interaction unlikely. Cimetidine Interaction not studied. No dose adjustment necessary.
Eintrag öffnenTriumeq · 4.5 · Clinically significant interaction unlikely. Cimetidine Interaction not studied. No dose adjustment necessary.
Eintrag öffnenTriumeq · 4.5 · Clinically significant interaction unlikely. Cytotoxics Cladribine/Lamivudine Interaction not studied. Concomi
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