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Vijoice · 4.5 · CYP3A4 inducers Once-daily administration of 600 mg rifampicin (a strong CYP3A4 inducer) for 7 days followed b
Eintrag öffnenVijoice · 4.5 · CYP3A4, CYP2C8, CYP2C9, CYP2C19 and CYP2B6 substrates No dose adjustment is required when co-administering alp
Eintrag öffnenVijoice · 4.5 · CYP3A4, CYP2C8, CYP2C9, CYP2C19 and CYP2B6 substrates No dose adjustment is required when co-administering alp
Eintrag öffnenVijoice · 4.5 · Co-administration with a strong CYP3A4 inducer decreases alpelisib AUC, which may reduce alpelisib efficacy. C
Eintrag öffnenVijoice · 4.5 · Co-administration with a strong CYP3A4 inducer decreases alpelisib AUC, which may reduce alpelisib efficacy. C
Eintrag öffnenVijoice · 4.5 · Hormonal contraceptives
Eintrag öffnenVijoice · 4.5 · Hormonal contraceptives
Eintrag öffnenVijoice · 4.5 · In a drug-drug interaction study, co-administration of alpelisib with everolimus, a sensitive CYP3A4 substrate
Eintrag öffnenVijoice · 4.5 · In a drug-drug interaction study, co-administration of alpelisib with everolimus, a sensitive CYP3A4 substrate
Eintrag öffnenVijoice · 4.5 · In healthy subjects, co-administration of a CYP2C9 substrate (S-warfarin) with alpelisib increased S- warfarin
Eintrag öffnenVijoice · 4.5 · In healthy subjects, co-administration of a CYP2C9 substrate (S-warfarin) with alpelisib increased S- warfarin
Eintrag öffnenVijoice · 4.5 · Interaction studies have only been performed in adult healthy volunteers and cancer patients (see section 5.2)
Eintrag öffnenVijoice · 4.5 · Interaction studies have only been performed in adult healthy volunteers and cancer patients (see section 5.2.
Eintrag öffnenVijoice · 4.5 · Medicinal products that may increase alpelisib plasma concentrations
Eintrag öffnenVijoice · 4.5 · Medicinal products that may increase alpelisib plasma concentrations
Eintrag öffnenVijoice · 4.5 · Medicinal products whose plasma concentrations may be altered by alpelisib
Eintrag öffnenVijoice · 4.5 · Medicinal products whose plasma concentrations may be altered by alpelisib
Eintrag öffnenVijoice · 4.5 · No clinical studies were conducted assessing the drug-drug interaction potential between alpelisib and hormona
Eintrag öffnenVijoice · 4.5 · No clinical studies were conducted assessing the drug-drug interaction potential between alpelisib and hormona
Eintrag öffnenVijoice · 4.5 · Substances that are substrates of transporters In vitro evaluations indicated that alpelisib (and/or its metab
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