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Xalkori · 4.5 · In vitro studies indicated that crizotinib is a weak inhibitor of uridine diphosphate glucuronosyltransferase
Eintrag öffnenXalkori · 4.5 · In vitro studies indicated that crizotinib is an inhibitor of CYP2B6. Therefore, crizotinib may have the poten
Eintrag öffnenXalkori · 4.5 · Interaction studies with other medicinal products have been performed in adults.
Eintrag öffnenXalkori · 4.5 · Pharmacodynamic interactions
Eintrag öffnenXalkori · 4.5 · Pharmacokinetic interactions
Eintrag öffnenXalkori · 4.5 · Physiologically-based pharmacokinetic (PBPK) simulations predicted a 17% increase in crizotinib steady-state A
Eintrag öffnenXalkori · 4.5 · The effect of a moderate inducer including but not limited to efavirenz or rifabutin is not clearly establishe
Eintrag öffnenXalkori · 4.5 · XALKORI 200 mg and 250 mg hard capsules Administration of a single 250 mg crizotinib dose of capsules followin
Eintrag öffnenXalkori · 4.5 · XALKORI granules in capsules for opening Administration of a single 250 mg crizotinib dose of oral granules in
Eintrag öffnenXalkori · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenXalkori · 4.8 Undesirable effects · 1
Eintrag öffnenXalkori · 4.8 · 17 The adverse reactions listed in Table 9 are presented by system organ class and frequency categories, defin
Eintrag öffnenXalkori · 4.8 · 18 Peripheral sensory neuropathy, Peroneal nerve palsy, Polyneuropathy, Sensory disturbance, Skin burning sens
Eintrag öffnenXalkori · 4.8 · 20 All Tumour Types (N=110) System organ class Very common Common Date of Data Cutoff: 03 Sep 2019. Event term
Eintrag öffnenXalkori · 4.8 · 21 Paediatric patients In clinical studies of 110 paediatric patients with various tumour types treated with c
Eintrag öffnenXalkori · 4.8 · 22 In a single-arm ECG substudy in adult patients (see section 5.2) using blinded manual ECG measurements 11 (
Eintrag öffnenXalkori · 4.8 · 23 All-causality, all grade, vision disorder, most commonly visual impairment, photopsia, vision blurred and v
Eintrag öffnenXalkori · 4.8 · 24 Adult patients with NSCLC All-causality complex renal cysts were experienced by 52 (3%) of 1722 adult patie
Eintrag öffnenXalkori · 4.8 · Across studies in adult patients with either ALK-positive or ROS1-positive advanced NSCLC (N=1722), Grade 3 or
Eintrag öffnenXalkori · 4.8 · Adult patients with NSCLC Across studies in adult patients with either ALK-positive or ROS1-positive advanced
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