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Xigduo · 4.5 · Interference with 1,5-anhydroglucitol (1,5-AG) assay Monitoring glycaemic control with 1,5-AG assay is not rec
Eintrag öffnenXigduo · 4.5 · Iodinated contrast agents Intravascular administration of iodinated contrast agents may lead to contrast induc
Eintrag öffnenXigduo · 4.5 · Metformin Concomitant use not recommended Cationic substances that are eliminated by renal tubular secretion (
Eintrag öffnenXigduo · 4.5 · No interaction studies have been performed for Xigduo. The following statements reflect the information availa
Eintrag öffnenXigduo · 4.5 · Paediatric population Interaction studies have only been performed in adults.
Eintrag öffnenXigduo · 4.5 · Pharmacokinetic interactions The metabolism of dapagliflozin is primarily via glucuronide conjugation mediated
Eintrag öffnenXigduo · 4.5 · Some medicinal products can adversely affect renal function which may increase the risk of lactic acidosis, e.
Eintrag öffnenXigduo · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenXigduo · 4.8 Undesirable effects · 1
Eintrag öffnenXigduo · 4.8 · 10 Table 2. Adverse reactions in dapagliflozin and metformin immediate-release clinical trial and post-marketi
Eintrag öffnenXigduo · 4.8 · 11 e Volume depletion includes, e.g. the predefined preferred terms: dehydration, hypovolaemia, hypotension. f
Eintrag öffnenXigduo · 4.8 · 12 In the DECLARE study with 17,160 type 2 diabetes mellitus patients and a median exposure time of 48 months,
Eintrag öffnenXigduo · 4.8 · 13 Increased creatinine Adverse reactions related to increased creatinine were grouped (e.g. decreased renal c
Eintrag öffnenXigduo · 4.8 · Cases of phimosis/acquired phimosis have been reported with dapagliflozin concurrent with genital infections a
Eintrag öffnenXigduo · 4.8 · Dapagliflozin Summary of the safety profile In the clinical studies in type 2 diabetes, more than 15,000 patie
Eintrag öffnenXigduo · 4.8 · Dapagliflozin Vulvovaginitis, balanitis and related genital infections In the 13-study safety pool, vulvovagin
Eintrag öffnenXigduo · 4.8 · Dapagliflozin plus metformin Summary of the safety profile In an analysis of 5 placebo-controlled dapagliflozi
Eintrag öffnenXigduo · 4.8 · Description of selected adverse reactions Dapagliflozin plus metformin Hypoglycaemia In studies with dapaglifl
Eintrag öffnenXigduo · 4.8 · Diabetic ketoacidosis In the DECLARE study, with a median exposure time of 48 months, events of DKA were repor
Eintrag öffnenXigduo · 4.8 · For studies of dapagliflozin as add-on to metformin or as add-on to sitagliptin (with or without metformin), t
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