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Zyllt · 4.5 · Medicinal products associated with bleeding risk: There is an increased risk of bleeding due to the potential
Eintrag öffnenZyllt · 4.5 · Medicinal products that are strong or moderate CYP2C19 inhibitors include, for example, omeprazole and esomepr
Eintrag öffnenZyllt · 4.5 · NSAIDs: in a clinical study conducted in healthy volunteers, the concomitant administration of clopidogrel and
Eintrag öffnenZyllt · 4.5 · Oral anticoagulants: the concomitant administration of clopidogrel with oral anticoagulants is not recommended
Eintrag öffnenZyllt · 4.5 · Other concomitant therapy: Inducers of CYP2C19 Since clopidogrel is metabolised to its active metabolite partl
Eintrag öffnenZyllt · 4.5 · Other medicinal products: A number of other clinical studies have been conducted with clopidogrel and other co
Eintrag öffnenZyllt · 4.5 · Proton Pump Inhibitors (PPI): Omeprazole 80 mg once daily administered either at the same time as clopidogrel
Eintrag öffnenZyllt · 4.5 · Rifampicin strongly induces CYP2C19, resulting in both an increased level of clopidogrel active metabolite and
Eintrag öffnenZyllt · 4.5 · Rosuvastatin: Clopidogrel has been shown to increase rosuvastatin exposure in patients by 2-fold (AUC) and 1.3
Eintrag öffnenZyllt · 4.5 · SSRIs: since SSRIs affect platelet activation and increase the risk of bleeding, the concomitant administratio
Eintrag öffnenZyllt · 4.5 · The pharmacokinetics of digoxin or theophylline were not modified by the co-administration of clopidogrel. Ant
Eintrag öffnenZyllt · 4.5 · Thrombolytics: the safety of the concomitant administration of clopidogrel, fibrin or non-fibrin specific thro
Eintrag öffnenZyllt · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenZyllt · 4.8 Undesirable effects · 1
Eintrag öffnenZyllt · 4.8 · 10 System Organ Common Uncommon Rare Very rare, not Class known* Blood and the Thrombocytopenia, Neutropenia,
Eintrag öffnenZyllt · 4.8 · 11 Ear and labyrinth Vertigo disorders Vascular Haematoma Serious disorders hemorrhage, hemorrhage of operativ
Eintrag öffnenZyllt · 4.8 · 12 Musculoskeletal, Musculo-skeletal connective tissue bleeding and bone (haemarthrosis), disorders arthritis,
Eintrag öffnenZyllt · 4.8 · 9 severity when compared with either clopidogrel alone or combined ASA and dipyridamole (adjusted common OR 2.
Eintrag öffnenZyllt · 4.8 · Bleeding is the most common reaction reported both in clinical studies as well as in post-marketing experience
Eintrag öffnenZyllt · 4.8 · In ACTIVE-A, the rate of major bleeding was greater in the clopidogrel + ASA group than in the placebo + ASA g
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