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CoAprovel · 4.5 · Antigout medicinal products: dosage adjustments of antigout medicinal products may be necessary as hydrochloro
Eintrag öffnenCoAprovel · 4.5 · Antigout medicinal products: dosage adjustments of antigout medicinal products may be necessary as hydrochloro
Eintrag öffnenCoAprovel · 4.5 · Antigout medicinal products: dosage adjustments of antigout medicinal products may be necessary as hydrochloro
Eintrag öffnenCombivir · 4.5 · Methadone dosage adjustment unlikely in majority of patients; occasionally methadone re-titration may be requi
Eintrag öffnenCotellic · 4.5 · Cobimetinib can be co-administered with mild inhibitors of CYP3A without dose adjustment.
Eintrag öffnenCotellic · 4.8 · No dose adjustment is recommended in patients with hepatic impairment (see section 5.2).
Eintrag öffnenCotellic · 4.8 · No pharmacokinetic trial in subjects with renal impairment has been conducted. Dose adjustment is not recommen
Eintrag öffnenCresemba · 4.5 · (CYP3A4/5 induction) Clarithromycin Not studied. No isavuconazole dose (strong CYP3A4/5 inhibitor) adjustment
Eintrag öffnenCresemba · 4.5 · 11 Digoxin Digoxin: No isavuconazole dose (P-gp substrate) AUCinf: ↑ 25% adjustment necessary. Cmax: ↑ 33% Dig
Eintrag öffnenCresemba · 4.5 · 8 Cmax: ↑ 1% Methadone: no dose adjustment 40% reduction in terminal half-life required. R-methadone (active o
Eintrag öffnenCresemba · 4.5 · No dose adjustment is warranted for moderate to mild CYP3A4/5 inhibitors.
Eintrag öffnenCresemba · 4.5 · No dose adjustment is warranted for moderate to mild CYP3A4/5 inhibitors.
Eintrag öffnenDescovy · 4.5 · Tenofovir alafenamide: AUC: ↑ 32% Cmax: ↔ Sofosbuvir (400 mg once daily)/ Sofosbuvir: No dose adjustment of so
Eintrag öffnenDescovy · 4.5 · Tenofovir alafenamide: AUC: ↑ 32% Cmax: ↔ Sofosbuvir (400 mg once daily)/ Sofosbuvir: No dose adjustment of so
Eintrag öffnenDescovy · 4.5 · Tenofovir alafenamide: AUC: ↔ Cmax: ↓ 21% Sofosbuvir/velpatasvir/ Sofosbuvir: No dose adjustment of sofosbuvir
Eintrag öffnenDescovy · 4.5 · Tenofovir alafenamide: AUC: ↔ Cmax: ↓ 21% Sofosbuvir/velpatasvir/ Sofosbuvir: No dose adjustment of sofosbuvir
Eintrag öffnenDovato · 4.5 · 8 available for this dose adjustment, see section 4.2). Fosamprenavir+ritonavir/ Dolutegravir Fosamprenavir/r
Eintrag öffnenDovato · 4.5 · 9 Trimethoprim/sulfamethoxazole Lamivudine: No dosage adjustment necessary. (Co-trimoxazole)/Lamivudine AUC
Eintrag öffnenDovato · 4.5 · Clinically significant interaction unlikely. Cimetidine Interaction not studied. No dosage adjustment necessar
Eintrag öffnenDovato · 4.5 · Lopinavir Ritonavir Darunavir+ritonavir/ Dolutegravir No dose adjustment is necessary. Dolutegravir AUC
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