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Emend · 4.8 · In an additional active-controlled clinical study in 1,169 adult patients receiving aprepitant and HEC, the ad
Eintrag öffnenEmend · 4.8 · In an additional active-controlled clinical study in 1,169 patients receiving aprepitant and HEC, the adverse
Eintrag öffnenEmend · 4.8 · Summary of the safety profile The safety profile of aprepitant was evaluated in approximately 6,500 adults in
Eintrag öffnenEmend · 4.8 · Summary of the safety profile The safety profile of aprepitant was evaluated in approximately 6,500 adults in
Eintrag öffnenEmend · 4.8 · The most common adverse reactions reported at a greater incidence in adults treated with the aprepitant regime
Eintrag öffnenEmend · 4.8 · The most common adverse reactions reported at a greater incidence in adults treated with the aprepitant regime
Eintrag öffnenIntuniv · 4.5 · Moderate CYP3A4/5 Strong CYP3A4/5 inhibitors CYP3A4 inducers inhibitors Aprepitant Boceprevir Bosentan Atazana
Eintrag öffnenIvemend · 4.5 · 5-HT3 antagonists Interaction studies with fosaprepitant 150 mg and 5-HT3 antagonists have not been conducted;
Eintrag öffnenIvemend · 4.5 · 7 Immunosuppressants Following a single 150 mg fosaprepitant dose, a transient moderate increase for two days
Eintrag öffnenIvemend · 4.5 · 8 Effect of other medicinal products on the pharmacokinetics of aprepitant resulting from administration of fo
Eintrag öffnenIvemend · 4.5 · Chemotherapeutic medicinal products Interaction studies with fosaprepitant 150 mg and chemotherapeutic medicin
Eintrag öffnenIvemend · 4.5 · Concomitant administration of fosaprepitant with active substances that strongly induce CYP3A4 activity (e.g.,
Eintrag öffnenIvemend · 4.5 · Diltiazem Interaction studies with fosaprepitant 150 mg and diltiazem have not been conducted; however, the fo
Eintrag öffnenIvemend · 4.5 · Diltiazem Interaction studies with fosaprepitant 150 mg and diltiazem have not been conducted; however, the fo
Eintrag öffnenIvemend · 4.5 · Effect of fosaprepitant on the pharmacokinetics of other active substances CYP3A4 inhibition As a weak inhibit
Eintrag öffnenIvemend · 4.5 · Fosaprepitant 150 mg, given as a single dose, is a weak inhibitor of CYP3A4. Fosaprepitant does not seem to in
Eintrag öffnenIvemend · 4.5 · Induction The fosaprepitant 150 mg single dose did not induce CYP3A4 on Days 1 and 4 in the midazolam interact
Eintrag öffnenIvemend · 4.5 · Interactions with other medicinal products following administration of intravenous fosaprepitant are likely to
Eintrag öffnenIvemend · 4.5 · Midazolam Fosaprepitant 150 mg administered as a single intravenous dose on Day 1 increased the AUC0-∞ of mida
Eintrag öffnenIvemend · 4.5 · The following information was derived from studies conducted with oral aprepitant and studies conducted with i
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