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Mekinist · 4.5 · Combination with dabrafenib
Eintrag öffnenMekinist · 4.5 · Patients should take trametinib as monotherapy or in combination with dabrafenib at least one hour prior to or
Eintrag öffnenMekinist · 4.5 · When trametinib is used in combination with dabrafenib see sections 4.4 and 4.5 of the dabrafenib SmPC for int
Eintrag öffnenMekinist · 4.8 · 12 The safety of trametinib in combination with dabrafenib has been evaluated in the integrated safety populat
Eintrag öffnenMekinist · 4.8 · 14 Table 5 Adverse reactions with trametinib in combination with dabrafenib
Eintrag öffnenMekinist · 4.8 · 17 treatment with trametinib monotherapy or in combination with dabrafenib have liver function monitored every
Eintrag öffnenMekinist · 4.8 · In clinical studies in other indications, the safety profile of trametinib in combination with dabrafenib in p
Eintrag öffnenMekinist · 4.8 · In the integrated safety population of trametinib in combination with dabrafenib (n=1 188) 27% of patients wer
Eintrag öffnenMekinist · 4.8 · Pancreatitis has been reported with dabrafenib in combination with trametinib. Please see the dabrafenib SmPC.
Eintrag öffnenMekinist · 4.8 · Patients treated with trametinib or combination with dabrafenib may develop ILD or pneumonitis. Trametinib sho
Eintrag öffnenMekinist · 4.8 · Renal failure has been reported with dabrafenib in combination with trametinib. Please see the dabrafenib SmPC
Eintrag öffnenMekinist · 4.8 · Rhabdomyolysis has been reported in patients taking trametinib alone or in combination with dabrafenib. Signs
Eintrag öffnenMekinist · 4.8 · The most common adverse reactions (incidence ≥20%) for trametinib in combination with dabrafenib were: pyrexia
Eintrag öffnenMekinist · 4.8 · The safety and efficacy of the combination of trametinib and dabrafenib have been evaluated in a multi-cohort,
Eintrag öffnenMekinist · 4.8 · Trametinib has been reported to decrease LVEF when used as monotherapy or in combination with dabrafenib. In c
Eintrag öffnenMekinist · 4.8 · Trametinib in combination with dabrafenib in patients with brain metastases
Eintrag öffnenSpexotras · 4.5 · Also refer to the guidance for medicinal product interactions for dabrafenib found in sections 4.4 and 4.5 of
Eintrag öffnenSpexotras · 4.8 · In clinical studies of paediatric patients treated with trametinib in combination with dabrafenib, the most co
Eintrag öffnenSpexotras · 4.8 · Rash Rash has been observed in 49% of paediatric patients in trametinib and dabrafenib combination studies in
Eintrag öffnenSpexotras · 4.8 · Renal failure Renal failure has been reported with trametinib in combination with dabrafenib. Renal failure du
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