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Forxiga · 4.8 · The overall safety profile of dapagliflozin in patients with chronic kidney disease was consistent with the kn
Eintrag öffnenForxiga · 4.8 · The overall safety profile of dapagliflozin in patients with heart failure was consistent with the known safet
Eintrag öffnenXigduo · 4.5 · Coadministration of multiple doses of dapagliflozin and metformin does not meaningfully alter the pharmacokine
Eintrag öffnenXigduo · 4.5 · Dapagliflozin Pharmacodynamic interactions Diuretics This medicinal product may add to the diuretic effect of
Eintrag öffnenXigduo · 4.5 · Effect of dapagliflozin on other medicinal products Dapagliflozin may increase renal lithium excretion and the
Eintrag öffnenXigduo · 4.5 · Effect of other medicinal products on dapagliflozin Interaction studies conducted in healthy subjects, using m
Eintrag öffnenXigduo · 4.5 · Following coadministration of dapagliflozin with mefenamic acid (an inhibitor of UGT1A9), a 55% increase in da
Eintrag öffnenXigduo · 4.5 · Following coadministration of dapagliflozin with rifampicin (an inducer of various active transporters and dru
Eintrag öffnenXigduo · 4.5 · In in vitro studies, dapagliflozin neither inhibited cytochrome P450 (CYP) 1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9
Eintrag öffnenXigduo · 4.5 · In interaction studies conducted in healthy subjects, using mainly a single-dose design, dapagliflozin did not
Eintrag öffnenXigduo · 4.5 · Pharmacokinetic interactions The metabolism of dapagliflozin is primarily via glucuronide conjugation mediated
Eintrag öffnenXigduo · 4.8 · 10 Table 2. Adverse reactions in dapagliflozin and metformin immediate-release clinical trial and post-marketi
Eintrag öffnenXigduo · 4.8 · Cases of phimosis/acquired phimosis have been reported with dapagliflozin concurrent with genital infections a
Eintrag öffnenXigduo · 4.8 · Dapagliflozin Summary of the safety profile In the clinical studies in type 2 diabetes, more than 15,000 patie
Eintrag öffnenXigduo · 4.8 · Dapagliflozin Vulvovaginitis, balanitis and related genital infections In the 13-study safety pool, vulvovagin
Eintrag öffnenXigduo · 4.8 · Dapagliflozin plus metformin Summary of the safety profile In an analysis of 5 placebo-controlled dapagliflozi
Eintrag öffnenXigduo · 4.8 · Description of selected adverse reactions Dapagliflozin plus metformin Hypoglycaemia In studies with dapaglifl
Eintrag öffnenXigduo · 4.8 · For studies of dapagliflozin as add-on to metformin or as add-on to sitagliptin (with or without metformin), t
Eintrag öffnenXigduo · 4.8 · In the DECLARE study, no increased risk of major hypoglycaemia was observed with dapagliflozin therapy compare
Eintrag öffnenXigduo · 4.8 · In the dapagliflozin cardiovascular outcomes study (DECLARE, see section 5.1), 8,574 patients received dapagli
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