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Ivabradine Accord · 4.5 · Grapefruit juice Ivabradine exposure was increased by 2-fold following the co-administration with grapefruit j
Eintrag öffnenIvabradine Accord · 4.5 · Interaction studies have only been performed in adults.
Eintrag öffnenIvabradine Accord · 4.5 · Ivabradine is metabolised by CYP3A4 only and it is a very weak inhibitor of this cytochrome. Ivabradine was sh
Eintrag öffnenIvabradine Accord · 4.5 · Moderate CYP3A4 inhibitors Specific interaction studies in healthy volunteers and patients have shown that the
Eintrag öffnenIvabradine Accord · 4.5 · Moderate CYP3A4 inhibitors The concomitant use of ivabradine with other moderate CYP3A4 inhibitors (e.g. fluco
Eintrag öffnenIvabradine Accord · 4.5 · Other concomitant use Specific interaction studies have shown no clinically significant effect of the followin
Eintrag öffnenIvabradine Accord · 4.5 · Paediatric population
Eintrag öffnenIvabradine Accord · 4.5 · Pharmacodynamic interactions
Eintrag öffnenIvabradine Accord · 4.5 · Pharmacokinetic interactions
Eintrag öffnenIvabradine Accord · 4.5 · Potassium-depleting diuretics (thiazide diuretics and loop diuretics)
Eintrag öffnenIvabradine Accord · 4.5 · Potent CYP3A4 inhibitors The concomitant use of potent CYP3A4 inhibitors such as azole antifungals (ketoconazo
Eintrag öffnenIvabradine Accord · 4.5 · QT prolonging medicinal products - Cardiovascular QT prolonging medicinal products (e.g. quinidine, disopyrami
Eintrag öffnenIvabradine Accord · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenIvabradine Accord · 4.8 Undesirable effects · 1
Eintrag öffnenIvabradine Accord · 4.8 · 8 Tabulated list of adverse reactions
Eintrag öffnenIvabradine Accord · 4.8 · 9 Description of selected adverse reactions
Eintrag öffnenIvabradine Accord · 4.8 · Bradycardia was reported by 3.3% of patients particularly within the first 2 to 3 months of treatment initiati
Eintrag öffnenIvabradine Accord · 4.8 · In the SHIFT trial more patients experienced episodes of increased blood pressure while treated with ivabradin
Eintrag öffnenIvabradine Accord · 4.8 · In the SIGNIFY study atrial fibrillation was observed in 5.3% of patients taking ivabradine compared to 3.8% i
Eintrag öffnenIvabradine Accord · 4.8 · Luminous phenomena (phosphenes) were reported by 14.5% of patients, described as a transient enhanced brightne
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