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Jentadueto · 4.5 · Sulphonylureas: Co-administration of multiple oral doses of 5 mg linagliptin and a single oral dose of 1.75 mg
Eintrag öffnenJentadueto · 4.5 · Sulphonylureas: The steady-state pharmacokinetics of 5 mg linagliptin were not changed by concomitant administ
Eintrag öffnenJentadueto · 4.5 · Warfarin: Multiple daily doses of 5 mg linagliptin did not alter the pharmacokinetics of S(-) or R(+) warfarin
Eintrag öffnenJentadueto · 4.8 · Description of selected adverse reactions Hypoglycaemia In one study linagliptin was given as add-on to metfor
Eintrag öffnenJentadueto · 4.8 · In the CARMELINA study, bullous pemphigoid was reported in 0.2% of patients treated with linagliptin and in no
Eintrag öffnenJentadueto · 4.8 · Linagliptin cardiovascular and renal safety study (CARMELINA) The CARMELINA study evaluated the cardiovascular
Eintrag öffnenJentadueto · 4.8 · Summary of the safety profile The safety of linagliptin 2.5 mg twice daily (or its bioequivalent of 5 mg once
Eintrag öffnenJentadueto · 4.8 · Table 2: Adverse reactions reported in patients who received linagliptin+metformin alone (as mono-components o
Eintrag öffnenJentadueto · 4.8 · Tabulated list of adverse reactions Adverse reactions reported in all clinical trials with the linagliptin+met
Eintrag öffnenJentadueto · 4.8 · The most frequently reported adverse reaction for linagliptin plus metformin was diarrhoea (1.6%) with a compa
Eintrag öffnenJentadueto · 4.8 · When linagliptin and metformin were administered in combination with insulin, hypoglycaemia was the most frequ
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Eintrag öffnenTrajenta · 4.5 · Digoxin: co-administration of multiple daily doses of 5 mg linagliptin with multiple doses of 0.25 mg digoxin
Eintrag öffnenTrajenta · 4.5 · Effects of linagliptin on other medicinal products In clinical studies, as described below, linagliptin had no
Eintrag öffnenTrajenta · 4.5 · In vitro assessment of interactions Linagliptin is a weak competitive and a weak to moderate mechanism-based i
Eintrag öffnenTrajenta · 4.5 · In vivo assessment of interactions Effects of other medicinal products on linagliptin Clinical data described
Eintrag öffnenTrajenta · 4.5 · Metformin: co-administration of multiple daily doses of 10 mg linagliptin with 850 mg metformin, an OCT substr
Eintrag öffnenTrajenta · 4.5 · Metformin: co-administration of multiple three times daily doses of 850 mg metformin with 10 mg linagliptin on
Eintrag öffnenTrajenta · 4.5 · Oral contraceptives: co-administration with 5 mg linagliptin did not alter the steady-state pharmacokinetics o
Eintrag öffnenTrajenta · 4.5 · Rifampicin: multiple co-administration of 5 mg linagliptin with rifampicin, a potent inductor of P-glycoprotei
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