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Leflunomide medac · 4.5 · 9 with warfarin alone. Therefore, when warfarin is co-administered, close INR follow-up and monitoring is reco
Eintrag öffnenLeflunomide medac · 4.5 · CYP450 inhibitors and inducers In vitro inhibition studies in human liver microsomes suggest that cytochrome P
Eintrag öffnenLeflunomide medac · 4.5 · Cholestyramine or activated charcoal It is recommended that patients receiving leflunomide are not treated wit
Eintrag öffnenLeflunomide medac · 4.5 · Effect of other medicinal products on leflunomide
Eintrag öffnenLeflunomide medac · 4.5 · Effect on BCRP (Breast Cancer Resistance Protein) and/or organic anion transporting polypeptide B1 and B3 (OAT
Eintrag öffnenLeflunomide medac · 4.5 · Effect on caffeine (CYP1A2 substrate) Repeated doses of A771726 decreased mean Cmax and AUC of caffeine (CYP1A
Eintrag öffnenLeflunomide medac · 4.5 · Effect on oral contraceptive (0.03 mg ethinylestradiol and 0.15 mg levonorgestrel) There was an increase in me
Eintrag öffnenLeflunomide medac · 4.5 · Effect on organic anion transporter 3 (OAT3) substrates There was an increase in mean cefaclor Cmax and AUC (1
Eintrag öffnenLeflunomide medac · 4.5 · Effect on repaglinide (CYP2C8 substrate) There was an increase in mean repaglinide Cmax and AUC (1.7- and 2.4-
Eintrag öffnenLeflunomide medac · 4.5 · Effect on warfarin (CYP2C9 substrate) Repeated doses of A771726 had no effect on the pharmacokinetics of S-war
Eintrag öffnenLeflunomide medac · 4.5 · In patients with rheumatoid arthritis, no pharmacokinetic interaction between the leflunomide (10 to 20 mg per
Eintrag öffnenLeflunomide medac · 4.5 · Increased side effects may occur in case of recent or concomitant use of hepatotoxic or haematotoxic medicinal
Eintrag öffnenLeflunomide medac · 4.5 · Interactions studies have only been performed in adults.
Eintrag öffnenLeflunomide medac · 4.5 · Methotrexate In a small (n = 30) study with co-administration of leflunomide (10 to 20 mg per day) with methot
Eintrag öffnenLeflunomide medac · 4.5 · NSAIDS/Corticosteroids If the patient is already receiving nonsteroidal anti-inflammatory drugs (NSAIDs) and/o
Eintrag öffnenLeflunomide medac · 4.5 · Oral contraceptives In a study in which leflunomide was given concomitantly with a triphasic oral contraceptiv
Eintrag öffnenLeflunomide medac · 4.5 · The following pharmacokinetic and pharmacodynamic interaction studies were conducted with A771726 (principal a
Eintrag öffnenLeflunomide medac · 4.5 · Vaccinations No clinical data are available on the efficacy and safety of vaccinations under leflunomide treat
Eintrag öffnenLeflunomide medac · 4.5 · Warfarin and other coumarin anticoagulants There have been case reports of increased prothrombin time, when le
Eintrag öffnenLeflunomide medac · 4.6 Fertility, pregnancy and lactation · 1
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