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Cholib · 4.5 · Effects on the pharmacokinetics of other medicinal products Fenofibrate and simvastatin are not CYP 3A4 inhibi
Eintrag öffnenCholib · 4.5 · Effects on the pharmacokinetics of other medicinal products Fenofibrate and simvastatin are not CYP 3A4 inhibi
Eintrag öffnenCholib · 4.5 · Fenofibrate and simvastatin are not inhibitors of CYP 2D6, CYP 2E1, or CYP 1A2. Fenofibrate is a mild to moder
Eintrag öffnenCholib · 4.5 · Fenofibrate and simvastatin are not inhibitors of CYP 2D6, CYP 2E1, or CYP 1A2. Fenofibrate is a mild to moder
Eintrag öffnenCholib · 4.5 · In a clinical trial, myopathy was reported in 6% of patients receiving simvastatin 80 mg and amiodarone, versu
Eintrag öffnenCholib · 4.5 · In a clinical trial, myopathy was reported in 6% of patients receiving simvastatin 80 mg and amiodarone, versu
Eintrag öffnenCholib · 4.5 · In one study the AUC of the simvastatin acid (SVA), a major active metabolite of simvastatin, was reduced by 4
Eintrag öffnenCholib · 4.5 · Interaction between simvastatin and fenofibrate Effects of repeated administration of fenofibrate on the pharm
Eintrag öffnenCholib · 4.5 · Interaction between simvastatin and fenofibrate Effects of repeated administration of fenofibrate on the pharm
Eintrag öffnenCholib · 4.5 · Interactions relevant to monotherapies Inhibitors of CYP 3A4 Simvastatin is a substrate of cytochrome P450 3A4
Eintrag öffnenCholib · 4.5 · Interactions relevant to monotherapies Inhibitors of CYP 3A4 Simvastatin is a substrate of cytochrome P450 3A4
Eintrag öffnenCholib · 4.5 · Other statins and fibrates Gemfibrozil increases the AUC of simvastatin acid by 1.9-fold, possibly due to inhi
Eintrag öffnenCholib · 4.5 · Other statins and fibrates Gemfibrozil increases the AUC of simvastatin acid by 1.9-fold, possibly due to inhi
Eintrag öffnenCholib · 4.5 · Rifampicin Because rifampicin is a potent CYP 3A4 inducer that interferes with simvastatin metabolism, patient
Eintrag öffnenCholib · 4.5 · Rifampicin Because rifampicin is a potent CYP 3A4 inducer that interferes with simvastatin metabolism, patient
Eintrag öffnenCholib · 4.5 · The repeated administration of simvastatin 40 or 80 mg, the highest dose registered, did not affect the plasma
Eintrag öffnenCholib · 4.5 · The repeated administration of simvastatin 40 or 80 mg, the highest dose registered, did not affect the plasma
Eintrag öffnenCholib · 4.5 · Vitamin K antagonists Fenofibrate and simvastatin enhance effects of Vitamin K antagonists and may increase th
Eintrag öffnenCholib · 4.5 · Vitamin K antagonists Fenofibrate and simvastatin enhance effects of Vitamin K antagonists and may increase th
Eintrag öffnenCholib · 4.5 · Whether fenofibrate had an effect on other active metabolites of simvastatin was not investigated.
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