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Begriffe & Kennungen
Mekinist · 4.8 · Elevations in blood pressure have been reported in association with trametinib as monotherapy and in combinati
Eintrag öffnenMekinist · 4.8 · Hepatic adverse reactions have been reported in clinical studies with trametinib as monotherapy and in combina
Eintrag öffnenMekinist · 4.8 · In clinical studies in other indications, the safety profile of trametinib in combination with dabrafenib in p
Eintrag öffnenMekinist · 4.8 · In the Phase III study with trametinib in patients with unresectable or metastatic melanoma (n=211), 49 patien
Eintrag öffnenMekinist · 4.8 · In the integrated safety population of trametinib in combination with dabrafenib (n=1 188) 27% of patients wer
Eintrag öffnenMekinist · 4.8 · New malignancies, cutaneous and non-cutaneous, can occur when trametinib is used in combination with dabrafeni
Eintrag öffnenMekinist · 4.8 · No dosage adjustment is required in patients with mild hepatic impairment (see section 5.2). Trametinib should
Eintrag öffnenMekinist · 4.8 · Pancreatitis has been reported with dabrafenib in combination with trametinib. Please see the dabrafenib SmPC.
Eintrag öffnenMekinist · 4.8 · Patients treated with trametinib or combination with dabrafenib may develop ILD or pneumonitis. Trametinib sho
Eintrag öffnenMekinist · 4.8 · Pyrexia has been reported in clinical studies with trametinib as monotherapy and in combination with dabrafeni
Eintrag öffnenMekinist · 4.8 · Renal failure has been reported with dabrafenib in combination with trametinib. Please see the dabrafenib SmPC
Eintrag öffnenMekinist · 4.8 · Rhabdomyolysis has been reported in patients taking trametinib alone or in combination with dabrafenib. Signs
Eintrag öffnenMekinist · 4.8 · Table 4 Adverse reactions with trametinib monotherapy
Eintrag öffnenMekinist · 4.8 · The most common adverse reactions (incidence ≥20%) for trametinib in combination with dabrafenib were: pyrexia
Eintrag öffnenMekinist · 4.8 · The safety and efficacy of the combination of trametinib and dabrafenib have been evaluated in a multi-cohort,
Eintrag öffnenMekinist · 4.8 · The safety of trametinib film-coated tablets has not been evaluated in prospective clinical studies of adolesc
Eintrag öffnenMekinist · 4.8 · The safety of trametinib monotherapy has been evaluated in the integrated safety population of 329 patients wi
Eintrag öffnenMekinist · 4.8 · Trametinib has been reported to decrease LVEF when used as monotherapy or in combination with dabrafenib. In c
Eintrag öffnenMekinist · 4.8 · Trametinib in combination with dabrafenib in patients with brain metastases
Eintrag öffnenSpexotras · 4.5 · As trametinib is metabolised predominantly via deacetylation mediated by hydrolytic enzymes (e.g. carboxyl-est
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