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18 angezeigte Treffer · Seite 2, keine Gesamtzahl für „vemurafenib“
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Zelboraf · 4.5 · Effects of concomitant medicines on vemurafenib In vitro studies suggest that CYP3A4 metabolism and glucuronid
Eintrag öffnenZelboraf · 4.5 · Effects of vemurafenib on Drug Metabolizing Enzymes Results from an in vivo drug-drug interaction study in met
Eintrag öffnenZelboraf · 4.5 · Effects of vemurafenib on drug transport systems In vitro studies have demonstrated that vemurafenib is an inh
Eintrag öffnenZelboraf · 4.5 · In a clinical study, co-administration of a single dose 960 mg of vemurafenib with rifampicin, significantly d
Eintrag öffnenZelboraf · 4.5 · Mild induction of CYP2B6 by vemurafenib was noted in vitro at a vemurafenib concentration of 10 µM. It is curr
Eintrag öffnenZelboraf · 4.5 · The effects of vemurafenib on medicinal products that are substrates of BCRP are unknown. It cannot be exclude
Eintrag öffnenZelboraf · 4.5 · The possible effect of vemurafenib on other transporters is currently unknown.
Eintrag öffnenZelboraf · 4.5 · Vemurafenib moderately inhibited CYP2C8 in vitro. The in vivo relevance of this finding is unknown, but a risk
Eintrag öffnenZelboraf · 4.8 · 10 Table 3: ADRs occurring in patients treated with vemurafenib in the phase II or phase III studyand events o
Eintrag öffnenZelboraf · 4.8 · Acute kidney injury (h) Cases of renal toxicity have been reported with vemurafenib ranging from creatinine el
Eintrag öffnenZelboraf · 4.8 · Dermatologic reactions (f) Severe dermatologic reactions have been reported in patients receiving vemurafenib,
Eintrag öffnenZelboraf · 4.8 · Gender During clinical trials with vemurafenib, grade 3 adverse reactions reported more frequently in females
Eintrag öffnenZelboraf · 4.8 · Paediatric population The safety of vemurafenib in children and adolescents has not been established. No new s
Eintrag öffnenZelboraf · 4.8 · Sarcoidosis (j) Cases of sarcoidosis have been reported in patients treated with vemurafenib, mostly involving
Eintrag öffnenZelboraf · 4.8 · Vemurafenib (%) Dacarbazine (%) Acute kidney injury cases* 10.0 1.4 Acute kidney injury cases associated with
Eintrag öffnenZelboraf · 4.8 · Vemurafenib (%) Dacarbazine (%) Change 1 grade from baseline to any grade 27.9 6.1 Change 1 grade from bas
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