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Granpidam · 4.5 · In a specific interaction study, where sildenafil (100 mg) was co-administered with amlodipine in hypertensive
Eintrag öffnenHarvoni · 4.5 · 57 d Lack of pharmacokinetics interaction bounds 70-143%. e These are drugs within class where similar interac
Eintrag öffnenHumira · 4.8 · * further information is found elsewhere in sections 4.3, 4.4 and 4.8 ** including open label extension studie
Eintrag öffnenHumira · 4.8 · * further information is found elsewhere in sections 4.3, 4.4 and 4.8 ** including open label extension studie
Eintrag öffnenHumira · 4.8 · * further information is found elsewhere in sections 4.3, 4.4 and 4.8 ** including open label extension studie
Eintrag öffnenIdacio · 4.8 · * further information is found elsewhere in sections 4.3, 4.4 and 4.8 ** including open label extension studie
Eintrag öffnenImlygic · 4.8 · The safety of Imlygic was evaluated in the pivotal study where 292 patients received at least 1 dose of Imlygi
Eintrag öffnenInaqovi · 4.8 · The safety of Inaqovi was evaluated in one Phase 3 study (ASTX727-02-EU) where 80 AML patients received the me
Eintrag öffnenInvokana · 4.8 · In one of the dedicated long-term cardiovascular studies (CANVAS), where adult patients were generally older w
Eintrag öffnenJylamvo · 4.5 · Particularly in the case of orthopaedic surgery where the risk of infection is high, combination therapy with
Eintrag öffnenKalydeco · 4.8 · 44 was interrupted in most patients with transaminase elevations > 5 × ULN. In all instances where dosing was
Eintrag öffnenKimmtrak · 4.8 · In Study IMCgp100-202 where 95 % of patients had preexisting liver metastasis, ALT/AST increase to ≥ Grade 1 w
Eintrag öffnenKyprolis · 4.5 · In vitro, carfilzomib inhibits OATP1B1 with an IC50 = 2.01 µM whereas it is unknown whether carfilzomib may or
Eintrag öffnenLumeblue (previously Methylthioninium chloride Cosmo) · 4.5 · Methylthioninium chloride induces CYP isozymes 1A2 and 2B6 in human hepatocytes culture, whereas it does not i
Eintrag öffnenLynozyfic · 4.5 · 14 products that are CYP substrates where minimal changes in concentration may lead to serious adverse reactio
Eintrag öffnenMiglustat Gen.Orph · 4.8 · Miglustat has been studied in indications where certain events reported as adverse reactions, such as neurolog
Eintrag öffnenMinjuvi · 4.8 · The adverse reaction frequencies from clinical trials are based on all-cause adverse event frequencies, where
Eintrag öffnenMvasi · 4.8 · Post-marketing adverse reactions are included in both tables 1 and 2, where applicable. Detailed information a
Eintrag öffnenMysildecard · 4.5 · In a specific interaction study, where sildenafil (100 mg) was co-administered with amlodipine in hypertensive
Eintrag öffnenNeupro · 4.8 · 23 In trials where the application sites were rotated as reflected in the instructions provided in SmPC and pa
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