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Adempas · 4.5 · Patients must not get pregnant during riociguat therapy (see section 4.3). Riociguat (2.5 mg 3 times daily) di
Eintrag öffnenAdempas · 4.5 · Pharmacodynamic interactions
Eintrag öffnenAdempas · 4.5 · Riociguat and its main metabolite are not inhibitors or inducers of major CYP isoforms (including CYP 3A4) or
Eintrag öffnenAdempas · 4.5 · Riociguat and its main metabolite are strong inhibitors of CYP1A1 in vitro. Therefore, clinically relevant dru
Eintrag öffnenAdempas · 4.5 · Riociguat and its main metabolite are strong inhibitors of CYP1A1 in vitro. Therefore, clinically relevant dru
Eintrag öffnenAdempas · 4.5 · Riociguat is cleared mainly via cytochrome P450-mediated (CYP1A1, CYP3A4, CYP3A5, CYP2J2) oxidative metabolism
Eintrag öffnenAdempas · 4.5 · Riociguat is cleared mainly via cytochrome P450-mediated (CYP1A1, CYP3A4, CYP3A5, CYP2J2) oxidative metabolism
Eintrag öffnenAdempas · 4.5 · Smoking In cigarette smokers riociguat exposure is reduced by 50-60% (see section 5.2). Therefore, patients ar
Eintrag öffnenAdempas · 4.5 · Soluble guanylate cyclase stimulators Concomitant use of riociguat with other soluble guanylate cyclase stimul
Eintrag öffnenAdempas · 4.5 · Soluble guanylate cyclase stimulators Concomitant use of riociguat with other soluble guanylate cyclase stimul
Eintrag öffnenAdempas · 4.5 · The concomitant use of riociguat with strong CYP3A4 inducers (e.g. phenytoin, carbamazepine, phenobarbitone or
Eintrag öffnenAdempas · 4.5 · The concomitant use of riociguat with strong CYP3A4 inducers (e.g. phenytoin, carbamazepine, phenobarbitone or
Eintrag öffnenAdempas · 4.5 · Warfarin/phenprocoumon Concomitant treatment of riociguat and warfarin did not alter prothrombin time induced
Eintrag öffnenAdempas · 4.5 · Warfarin/phenprocoumon Concomitant treatment of riociguat and warfarin did not alter prothrombin time induced
Eintrag öffnenAdempas · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenAdempas · 4.6 Fertility, pregnancy and lactation · 2
Eintrag öffnenAdempas · 4.8 Undesirable effects · 1
Eintrag öffnenAdempas · 4.8 Undesirable effects · 2
Eintrag öffnenAdempas · 4.8 · 10 uncontrolled long term extension studies the safety profile was similar to that observed in the placebo con
Eintrag öffnenAdempas · 4.8 · 11 to 16 weeks (see section 4.2), followed by an optional long-term extension phase. Most common adverse react
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