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Begriffe & Kennungen
Aptivus · 4.5 · Interaction studies have only been performed in adults.
Eintrag öffnenAptivus · 4.5 · Interaction table Interactions between Aptivus and co-administered medicinal products are listed in the table
Eintrag öffnenAptivus · 4.5 · It is difficult to predict the net effect of Aptivus co-administered with low dose ritonavir on oral bioavaila
Eintrag öffnenAptivus · 4.5 · Known and theoretical interactions with selected antiretrovirals and non-antiretroviral medicinal products are
Eintrag öffnenAptivus · 4.5 · Mechanism unknown Itraconazole Based on theoretical Itraconazole or ketoconazole Ketoconazole considerations t
Eintrag öffnenAptivus · 4.5 · Mechanism unknown Meperidine Tipranavir, co-administered with Dosage increase and long-term No interaction stu
Eintrag öffnenAptivus · 4.5 · Mechanism unknown. Emtricitabine Potential interactions with renal No dosage adjustment necessary No interacti
Eintrag öffnenAptivus · 4.5 · Metabolic profile of tipranavir Tipranavir is a substrate, an inducer and an inhibitor of cytochrome P450 CYP3
Eintrag öffnenAptivus · 4.5 · No clinically significant change is observed in tipranavir PK parameters. Rifampicin Co-administration of prot
Eintrag öffnenAptivus · 4.5 · Pharmacokinetic enhancer Cobicistat and cobicistat- When co-administered, tipranavir Aptivus/ritonavir should
Eintrag öffnenAptivus · 4.5 · Ritonavir is a potent inhibitor of CYP3A4 and therefore affect drugs metabolised by this enzyme. Triazolam Bas
Eintrag öffnenAptivus · 4.5 · S-methadone Cmax ↓ 62% S-methadone AUC ↓ 63%
Eintrag öffnenAptivus · 4.5 · Simvastatin The HMG-CoA reductase The concomitant use of Aptivus, Lovastatin inhibitors simvastatin and co-adm
Eintrag öffnenAptivus · 4.5 · Steady-state tipranavir/r Digoxin Cmax ↓ 38% Digoxin AUC ↔ Trazodone In a pharmacokinetic study The combinatio
Eintrag öffnenAptivus · 4.5 · Studies in human liver microsomes indicated tipranavir is an inhibitor of CYP 1A2, CYP 2C9, CYP 2C19 and CYP 2
Eintrag öffnenAptivus · 4.5 · The decrease in tipranavir concentrations may result in decreased effectiveness.
Eintrag öffnenAptivus · 4.5 · The increase in carbamazepine total PK parameters is not expected to have clinical consequences.
Eintrag öffnenAptivus · 4.5 · The interaction profile of Aptivus, co-administered with low dose ritonavir, is complex and requires special a
Eintrag öffnenAptivus · 4.5 · The mechanism of action is thought to be induction of glucuronosyltransferase by tipranavir/r.
Eintrag öffnenAptivus · 4.5 · Tipranavir Cmin ↓ 61% (compared to historical data)
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