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Comtess · 4.5 · 4 and selegiline were observed in repeated-dose studies in parkinsonian patients. However, the experience of t
Eintrag öffnenComtess · 4.5 · Due to its affinity to cytochrome P450 2C9 in vitro (see section 5.2), entacapone may potentially interfere wi
Eintrag öffnenComtess · 4.5 · Entacapone binds to human albumin binding site II which also binds several other medicinal products, including
Eintrag öffnenComtess · 4.5 · Entacapone may be used with selegiline (a selective MAO-B inhibitor), but the daily dose of selegiline should
Eintrag öffnenComtess · 4.5 · Entacapone may form chelates with iron in the gastrointestinal tract. Entacapone and iron preparations should
Eintrag öffnenComtess · 4.5 · In single-dose studies in healthy volunteers, no interactions were observed between entacapone and imipramine
Eintrag öffnenComtess · 4.5 · No interaction of entacapone with carbidopa has been observed with the recommended treatment schedule. Pharmac
Eintrag öffnenComtess · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenComtess · 4.8 Undesirable effects · 1
Eintrag öffnenComtess · 4.8 · 5 diarrhoea. Urine may be discoloured reddish-brown by entacapone, but this is a harmless phenomenon.
Eintrag öffnenComtess · 4.8 · 6 be estimated from the available data, since no valid estimate can be derived from clinical trials or epidemi
Eintrag öffnenComtess · 4.8 · Description of selected adverse reactions Entacapone in association with levodopa has been associated with iso
Eintrag öffnenComtess · 4.8 · Dyskinesias (27%), nausea (11%), diarrhoea (8%), abdominal pain (7%) and dry mouth (4.2%) were reported signif
Eintrag öffnenComtess · 4.8 · Impulse control disorders: Pathological gambling, increased libido, hypersexuality, compulsive spending or buy
Eintrag öffnenComtess · 4.8 · Isolated cases of NMS have been reported following abrupt reduction or discontinuation of entacapone and other
Eintrag öffnenComtess · 4.8 · Isolated cases of rhabdomyolysis have been reported.
Eintrag öffnenComtess · 4.8 · Psychiatric disorders Common: Insomnia, hallucinations, confusion, paroniria Very rare: Agitation Nervous syst
Eintrag öffnenComtess · 4.8 · Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medi
Eintrag öffnenComtess · 4.8 · Some of the adverse reactions, such as dyskinesia, nausea, and abdominal pain, may be more common with the hig
Eintrag öffnenComtess · 4.8 · Summary of the safety profile The most frequent adverse reactions caused by entacapone relate to the increased
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