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Begriffe & Kennungen
Cotellic · 4.8 · Adverse drug reactions (ADRs) are based on results from a multi-centre, randomised, double-blind, placebo-cont
Eintrag öffnenCotellic · 4.8 · Bleeding events have been reported more frequently in the Cotellic plus vemurafenib arm than in the placebo pl
Eintrag öffnenCotellic · 4.8 · Blood creatine phosphokinase increase Asymptomatic increases in blood CPK levels were observed with a higher f
Eintrag öffnenCotellic · 4.8 · Cases of serous retinopathy have been reported in patients treated with Cotellic (see section 4.4.) For patien
Eintrag öffnenCotellic · 4.8 · Changes in reported Cobimetinib plus Placebo plus vemurafenib laboratory data vemurafenib (n = 246) (n = 247)
Eintrag öffnenCotellic · 4.8 · Cutaneous squamous cell carcinoma has been reported with a lower frequency in the Cotellic plus vemurafenib ar
Eintrag öffnenCotellic · 4.8 · Cutaneous squamous cell carcinoma, keratoacanthoma and hyperkeratosis
Eintrag öffnenCotellic · 4.8 · Decrease in LVEF from baseline has been reported in patients receiving Cotellic (see section 4.4). LVEF should
Eintrag öffnenCotellic · 4.8 · Description of selected adverse reactions
Eintrag öffnenCotellic · 4.8 · Elderly patients
Eintrag öffnenCotellic · 4.8 · Eye disorders Serous retinopathya, Visual impairment Blurred vision
Eintrag öffnenCotellic · 4.8 · Haemorrhage
Eintrag öffnenCotellic · 4.8 · Hepatic impairment
Eintrag öffnenCotellic · 4.8 · In Study GO28141, the most common adverse reactions (>20%) observed with a higher frequency in the Cotellic pl
Eintrag öffnenCotellic · 4.8 · In the Phase III study with Cotellic in combination with vemurafenib in patients with unresectable or metastat
Eintrag öffnenCotellic · 4.8 · Laboratory abnormalities
Eintrag öffnenCotellic · 4.8 · Left ventricular dysfunction
Eintrag öffnenCotellic · 4.8 · Liver laboratory abnormalities Liver laboratory abnormalities, specifically ALT, AST, and ALP have been observ
Eintrag öffnenCotellic · 4.8 · Musculoskeletal and Rhabdomyolysis*** connective tissue disorders General disorders and Pyrexia, Chills, Oedem
Eintrag öffnenCotellic · 4.8 · Neoplasms benign, Basal cell carcinoma, malignant and Cutaneous squamous unspecified (incl. cysts cell carcino
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