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Evotaz · 4.5 · Atazanavir is metabolised in the liver through CYP3A4. Cobicistat is a CYP3A substrate and is metabolised to a
Eintrag öffnenEvotaz · 4.5 · Clarithromycin may increase concentrations of atazanavir and cobicistat. Exposure to clarithromycin is expecte
Eintrag öffnenEvotaz · 4.5 · Co-administration of EVOTAZ with grazoprevir-containing products, including elbasvir/grazoprevir fixed dose co
Eintrag öffnenEvotaz · 4.5 · Co-administration of EVOTAZ with medicinal products that are moderate to weak inducers of CYP3A may result in
Eintrag öffnenEvotaz · 4.5 · Co-administration of EVOTAZ with medicinal products that inhibit CYP3A may result in increased plasma concentr
Eintrag öffnenEvotaz · 4.5 · Co-administration of nevirapine and cobicistat is expected to decrease cobicistat plasma concentrations while
Eintrag öffnenEvotaz · 4.5 · Co-administration of tenofovir alafenamide with cobicistat is expected to increase tenofovir alafenamide and t
Eintrag öffnenEvotaz · 4.5 · Co-administration with CYP3A- metabolised corticosteroids is not recommended unless the potential benefit to t
Eintrag öffnenEvotaz · 4.5 · Cobicistat is a strong mechanism-based CYP3A inhibitor and a weak CYP2D6 inhibitor. Cobicistat inhibits the tr
Eintrag öffnenEvotaz · 4.5 · Complex or unknown mechanisms of drug interaction preclude extrapolation of ritonavir drug interactions to cer
Eintrag öffnenEvotaz · 4.5 · Concentration of fluconazole may be increased if co-administered with cobicistat.
Eintrag öffnenEvotaz · 4.5 · Concentrations of atazanavir were not significantly affected. buprenorphine/naloxone in buprenorophine AUC: ↑3
Eintrag öffnenEvotaz · 4.5 · Concomitant use contraindicated Co-administration of medicinal products that are substrates of CYP3A and have
Eintrag öffnenEvotaz · 4.5 · Concomitant use not recommended Co-administration of EVOTAZ with medicinal products containing ritonavir or co
Eintrag öffnenEvotaz · 4.5 · Drug interaction trials were not conducted for EVOTAZ. As EVOTAZ contains atazanavir and cobicistat, any inter
Eintrag öffnenEvotaz · 4.5 · Effect on atazanavir and ritonavir exposure has not been studied. Expected: ↔ atazanavir ↔ ritonavir
Eintrag öffnenEvotaz · 4.5 · Effects of co-administration of EVOTAZ on progestin and estrogen are unknown. drosperinone/ethinyloestradiol d
Eintrag öffnenEvotaz · 4.5 · Elbasvir concentrations were increased when co-administered with atazanavir/ritonavir.
Eintrag öffnenEvotaz · 4.5 · Grazoprevir concentrations were greatly increased when co-administered with atazanavir/ritonavir. elbasvir 50
Eintrag öffnenEvotaz · 4.5 · Increase monitoring for adverse reactions.
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