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Lenvima · 4.8 · Dose interruption of lenvatinib due to an adverse reaction occurred in 63.2% of patients. Dose interruption of
Eintrag öffnenLenvima · 4.8 · Dose reduction of lenvatinib due to adverse reactions occurred in 67.0% of patients. The most common (occurrin
Eintrag öffnenLenvima · 4.8 · Ethnic origin
Eintrag öffnenLenvima · 4.8 · Females had a higher incidence of hypertension (including Grade 3 or 4 hypertension), proteinuria, and PPE, wh
Eintrag öffnenLenvima · 4.8 · Females had a higher incidence of hypertension, fatigue, ECG QT prolongation and alopecia. Men had a higher in
Eintrag öffnenLenvima · 4.8 · For additional safety information when lenvatinib is administered in combination, refer to the SmPC for the re
Eintrag öffnenLenvima · 4.8 · Frequencies are defined as: Very common (≥1/10) Common (≥1/100 to <1/10) Uncommon (≥1/1,000 to <1/100)
Eintrag öffnenLenvima · 4.8 · Gastrointestinal perforation and fistula formation (see section 4.4)
Eintrag öffnenLenvima · 4.8 · Haemorrhage (see section 4.4)
Eintrag öffnenLenvima · 4.8 · Hepatic impairment
Eintrag öffnenLenvima · 4.8 · Hepatotoxicity (see section 4.4)
Eintrag öffnenLenvima · 4.8 · Hypertension (see section 4.4)
Eintrag öffnenLenvima · 4.8 · Hypocalcaemia (see section 4.4)
Eintrag öffnenLenvima · 4.8 · In 452 patients with RAI-refractory DTC, dose reduction and discontinuation were the actions taken for an adve
Eintrag öffnenLenvima · 4.8 · In 496 patients with HCC, dose modification (interruption or reduction) and discontinuation were the actions t
Eintrag öffnenLenvima · 4.8 · In Phase 1 (combination dose-finding cohort) of Study 216, the most frequently (≥40%) reported adverse drug re
Eintrag öffnenLenvima · 4.8 · In patients with relapsed/refractory osteosarcoma, pneumothorax was reported at a frequency higher than that o
Eintrag öffnenLenvima · 4.8 · In the OLIE study (Study 230), the most frequently (≥35%) reported adverse drug reactions were hypothyroidism,
Eintrag öffnenLenvima · 4.8 · In the Phase 3 REFLECT trial (see section 5.1), 7.1% of lenvatinib-treated patients developed a renal failure/
Eintrag öffnenLenvima · 4.8 · In the Phase 3 REFLECT trial (see section 5.1), 89.6% of patients had a baseline TSH level of less than the up
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