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Mysildecard · 4.5 · Sildenafil had no clinically significant impact on the plasma levels of oral contraceptives (ethinyloestradiol
Eintrag öffnenMysildecard · 4.5 · Sildenafil had no significant effect on atorvastatin exposure (AUC increased 11%), suggesting that sildenafil
Eintrag öffnenMysildecard · 4.5 · Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 > 150 μM
Eintrag öffnenMysildecard · 4.5 · Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9
Eintrag öffnenMysildecard · 4.5 · Single doses of antacid (magnesium hydroxide/aluminium hydroxide) did not affect the bioavailability of silden
Eintrag öffnenMysildecard · 4.5 · The efficacy and safety of sildenafil co-administered with other treatments for pulmonary arterial hypertensio
Eintrag öffnenMysildecard · 4.5 · The most potent of the CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have effec
Eintrag öffnenMysildecard · 4.5 · The population pharmacokinetic analysis in pulmonary arterial hypertension patients suggested that co-administ
Eintrag öffnenMysildecard · 4.5 · The safety and efficacy of sildenafil when co-administered with other PDE5 inhibitors has not been studied in
Eintrag öffnenMysildecard · 4.5 · There are no data on the interaction of sildenafil and non-specific phosphodiesterase inhibitors such as theop
Eintrag öffnenMysildecard · 4.5 · When a single 100 mg dose of sildenafil was administered with erythromycin, a moderate CYP3A4 inhibitor, at st
Eintrag öffnenMysildecard · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenMysildecard · 4.8 Undesirable effects · 1
Eintrag öffnenMysildecard · 4.8 · 10 Table 1: Adverse reactions from sildenafil placebo-controlled studies in PAH and post-marketing experience
Eintrag öffnenMysildecard · 4.8 · 11 MedDRA system organ class (V.14.0) Adverse reaction Uncommon penile haemorrhage, haematospermia, gynaecomas
Eintrag öffnenMysildecard · 4.8 · Adverse reactions which occurred in > 1% of sildenafil-treated patients and were more frequent (> 1% differenc
Eintrag öffnenMysildecard · 4.8 · In a placebo-controlled study of sildenafil as an adjunct to intravenous epoprostenol in pulmonary arterial hy
Eintrag öffnenMysildecard · 4.8 · In a study to assess the effects of different dose levels of sildenafil the safety data for sildenafil 20 mg T
Eintrag öffnenMysildecard · 4.8 · In the pivotal placebo-controlled study of sildenafil in pulmonary arterial hypertension, a total of 207 patie
Eintrag öffnenMysildecard · 4.8 · In the placebo-controlled study of sildenafil in patients 1 to 17 years of age with pulmonary arterial hyperte
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