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Pyrukynd · 4.8 · 8 Insomnia In ACTIVATE, insomnia was reported with a similar incidence between patients who received Pyrukynd
Eintrag öffnenPyrukynd · 4.8 · Acute haemolysis Abrupt interruption or discontinuation of Pyrukynd can lead to acute haemolysis (see section
Eintrag öffnenPyrukynd · 4.8 · Adverse reactions are listed by MedDRA system organ class and frequency: very common (≥ 1/10); common (≥ 1/100
Eintrag öffnenPyrukynd · 4.8 · Adverse reactions are listed by MedDRA system organ class and frequency: very common (≥ 1/10); common (≥ 1/100
Eintrag öffnenPyrukynd · 4.8 · Blood testosterone increased (males) Oestradiol decreased (males)
Eintrag öffnenPyrukynd · 4.8 · Changes in sex hormone levels Mitapivat is a weak aromatase inhibitor in vitro. In ACTIVATE, 1 of 16 (6.3%) ma
Eintrag öffnenPyrukynd · 4.8 · Changes in sex hormone levels Mitapivat is a weak aromatase inhibitor in vitro. In ENERGIZE, 15 of 46 (32.6%)
Eintrag öffnenPyrukynd · 4.8 · Description of selected adverse reactions
Eintrag öffnenPyrukynd · 4.8 · Description of selected adverse reactions
Eintrag öffnenPyrukynd · 4.8 · Hypertransaminasaemia In ENERGIZE and ENERGIZE-T, 2 of 301 patients (0.66%) treated with Pyrukynd experienced
Eintrag öffnenPyrukynd · 4.8 · In a Phase 2 study, 2 of 52 patients (3.8%) experienced haemolysis upon sudden withdrawal of Pyrukynd, includi
Eintrag öffnenPyrukynd · 4.8 · Insomnia In ENERGIZE, insomnia was reported in 35 of 129 (27.1%) patients who received Pyrukynd and 5 of 63 (7
Eintrag öffnenPyrukynd · 4.8 · Oestradiol decreased (males)
Eintrag öffnenPyrukynd · 4.8 · Psychiatric disorders Insomnia Nervous system Headache Dizziness disorders Cardiac disorders Palpitations Hepa
Eintrag öffnenPyrukynd · 4.8 · Reporting of suspected adverse reactions
Eintrag öffnenPyrukynd · 4.8 · Reporting of suspected adverse reactions
Eintrag öffnenPyrukynd · 4.8 · Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows con
Eintrag öffnenPyrukynd · 4.8 · Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows con
Eintrag öffnenPyrukynd · 4.8 · Summary of the safety profile
Eintrag öffnenPyrukynd · 4.8 · Summary of the safety profile
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