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Retsevmo · 4.5 · Selpercatinib is a substrate for P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) in vitro, h
Eintrag öffnenRetsevmo · 4.5 · Selpercatinib is a substrate for P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) in vitro, h
Eintrag öffnenRetsevmo · 4.5 · Selpercatinib is an in vitro inhibitor of P-gp and BCRP. In vivo, selpercatinib increased Cmax and AUC of dabi
Eintrag öffnenRetsevmo · 4.5 · Selpercatinib is an in vitro inhibitor of P-gp and BCRP. In vivo, selpercatinib increased Cmax and AUC of dabi
Eintrag öffnenRetsevmo · 4.5 · Selpercatinib metabolism is through CYP3A4. Therefore, medicinal products that can influence CYP3A4 enzyme act
Eintrag öffnenRetsevmo · 4.5 · Selpercatinib metabolism is through CYP3A4. Therefore, medicinal products that can influence CYP3A4 enzyme act
Eintrag öffnenRetsevmo · 4.5 · Sensitive CYP2C8 substrates Selpercatinib increased the Cmax and AUC of repaglinide (a substrate of CYP2C8) by
Eintrag öffnenRetsevmo · 4.5 · Sensitive CYP2C8 substrates Selpercatinib increased the Cmax and AUC of repaglinide (a substrate of CYP2C8) by
Eintrag öffnenRetsevmo · 4.5 · Sensitive CYP3A4 substrates Selpercatinib increased Cmax and AUC of midazolam (a CYP3A4 substrate) by approxim
Eintrag öffnenRetsevmo · 4.5 · Sensitive CYP3A4 substrates Selpercatinib increased Cmax and AUC of midazolam (a CYP3A4 substrate) by approxim
Eintrag öffnenRetsevmo · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenRetsevmo · 4.6 Fertility, pregnancy and lactation · 2
Eintrag öffnenRetsevmo · 4.8 Undesirable effects · 1
Eintrag öffnenRetsevmo · 4.8 Undesirable effects · 2
Eintrag öffnenRetsevmo · 4.8 · 11 Table 5 Adverse drug reactions in patients receiving selpercatinib (N=1188)
Eintrag öffnenRetsevmo · 4.8 · 12 MedDRA system MedDRA preferred term Frequency of all Frequency of Grade organ class Grades ≥3 Haemoglobin d
Eintrag öffnenRetsevmo · 4.8 · 13 u Oedema includes oedema peripheral, face oedema, periorbital oedema, swelling face, localised oedema, peri
Eintrag öffnenRetsevmo · 4.8 · 14 maximum systolic blood pressure greater than 160 mm Hg). Grade 4 treatment emergent hypertension was report
Eintrag öffnenRetsevmo · 4.8 · 15 Tabulated list of adverse drug reactions in LIBRETTO-121
Eintrag öffnenRetsevmo · 4.8 · 16 MedDRA system MedDRA preferred Frequency of all Frequency of Grade ≥ 3 organ class term Grades# Alkaline ph
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