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Symtuza · 4.5 · Table 1: Interactions between the individual components of Symtuza and other medicinal products INTERACTIONS A
Eintrag öffnenSymtuza · 4.5 · Tenofovir alafenamide Tenofovir alafenamide is transported by P-glycoprotein (P-gp) and breast cancer resistan
Eintrag öffnenSymtuza · 4.5 · Tenofovir alafenamide is not an inhibitor of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, or CYP2D6 in vitro. It i
Eintrag öffnenSymtuza · 4.5 · The below list of examples of interactions is not comprehensive and therefore the label of each medicinal prod
Eintrag öffnenSymtuza · 4.5 · The combination of avanafil and Avanafil Symtuza is contraindicated (see section 4.3). For the treatment of pu
Eintrag öffnenSymtuza · 4.5 · The interaction profile of darunavir depends on whether ritonavir or cobicistat is used as a pharmacokinetic e
Eintrag öffnenSymtuza · 4.5 · This recommendation is different from ritonavir-boosted darunavir. Consult the Summary of Product Characterist
Eintrag öffnenSymtuza · 4.5 · Ticagrelor Based on theoretical Concomitant administration of considerations co-administration of Symtuza with
Eintrag öffnenSymtuza · 4.5 · Unlike ritonavir, cobicistat is not an inducer of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or UGT1A1. If switch
Eintrag öffnenSymtuza · 4.5 · Voriconazole Concentrations of voriconazole Voriconazole should not be may increase or decrease when combined
Eintrag öffnenSymtuza · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenSymtuza · 4.8 Undesirable effects · 1
Eintrag öffnenSymtuza · 4.8 · 19 Table 2 MedDRA system organ class Adverse reaction Frequency category Blood and lymphatic system disorders
Eintrag öffnenSymtuza · 4.8 · 20 Investigations common increased blood creatinine a Additional adverse reactions only seen with darunavir/ri
Eintrag öffnenSymtuza · 4.8 · 21 onset is more variable, and these events can occur many months after initiation of treatment (see section 4
Eintrag öffnenSymtuza · 4.8 · 22 Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the m
Eintrag öffnenSymtuza · 4.8 · Among 1 968 treatment-experienced patients receiving darunavir co-administered with ritonavir 600/100 mg twice
Eintrag öffnenSymtuza · 4.8 · Bleeding in haemophiliac patients There have been reports of increased spontaneous bleeding in haemophiliac pa
Eintrag öffnenSymtuza · 4.8 · Decrease estimated creatinine clearance Cobicistat increases serum creatinine due to inhibition of tubular sec
Eintrag öffnenSymtuza · 4.8 · Description of selected adverse reactions Rash Rash is a common adverse reaction in patients treated with daru
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