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Vegzelma · 4.8 · GI-vaginal fistulae in study GOG-0240 In a trial of patients with persistent, recurrent or metastatic cervical
Eintrag öffnenVegzelma · 4.8 · Gastrointestinal haemorrhages, including rectal bleeding and melaena have been reported in colorectal cancer p
Eintrag öffnenVegzelma · 4.8 · Grade 3-5 (NCI-CTCAE v.3) venous thromboembolic reactions have been reported in up to 7.8% of patients treated
Eintrag öffnenVegzelma · 4.8 · Haemorrhage (see section 4.4) In clinical trials across all indications the overall incidence of NCI-CTCAE v.3
Eintrag öffnenVegzelma · 4.8 · Hypersensitivity reactions (including anaphylactic shock)/infusion reactions (see section 4.4 and Post-marketi
Eintrag öffnenVegzelma · 4.8 · Hypertension (see section 4.4) In clinical trials, with the exception of study JO25567, the overall incidence
Eintrag öffnenVegzelma · 4.8 · Hypertension was generally adequately controlled with oral anti-hypertensives such as angiotensin-converting e
Eintrag öffnenVegzelma · 4.8 · In bevacizumab clinical trials, gastrointestinal fistulae (all grade) have been reported with an incidence of
Eintrag öffnenVegzelma · 4.8 · In clinical trials across indications, the overall incidence of venous thromboembolic reactions ranged from 2.
Eintrag öffnenVegzelma · 4.8 · In clinical trials of metastatic carcinoma of the colon or rectum, there was no increased risk of post-operati
Eintrag öffnenVegzelma · 4.8 · In clinical trials of ovarian cancer, Grade 3-5 wound healing complications were observed in up to 1.8% of pat
Eintrag öffnenVegzelma · 4.8 · In clinical trials, the overall incidence of arterial thromboembolic reactions ranged up to 3.8% in the bevaci
Eintrag öffnenVegzelma · 4.8 · In locally recurrent and metastatic breast cancer trials, Grade 3-5 wound healing complications were observed
Eintrag öffnenVegzelma · 4.8 · In most clinical trials of bevacizumab, patients with pre-existing CHF of NYHA (New York Heart Association) II
Eintrag öffnenVegzelma · 4.8 · In one clinical trial evaluating bevacizumab in combination with 5-fluorouracil/folinic acid, AVF2192g, patien
Eintrag öffnenVegzelma · 4.8 · In patients developing PRES, early recognition of symptoms with prompt treatment of specific symptoms includin
Eintrag öffnenVegzelma · 4.8 · In patients with NSCLC excluding predominant squamous histology, all Grade reactions were seen with a frequenc
Eintrag öffnenVegzelma · 4.8 · In study BO20924 of bevacizumab with current standard of care in rhabdomyosarcoma and non-rhabdomyosarcoma sof
Eintrag öffnenVegzelma · 4.8 · In study BO25041 of bevacizumab added to postoperative radiation therapy (RT) with concomitant and adjuvant te
Eintrag öffnenVegzelma · 4.8 · In study JO25567, all grade hypertension was observed in 77.3% of the patients who received bevacizumab in com
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