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Xalkori · 4.8 · Adult patients with NSCLC Across studies in adult patients with either ALK-positive or ROS1-positive advanced
Eintrag öffnenXalkori · 4.8 · Adult patients with NSCLC Drug-induced hepatotoxicity with fatal outcome occurred in 0.1% of 1722 adult patien
Eintrag öffnenXalkori · 4.8 · Adult patients with NSCLC In clinical studies with crizotinib in adult patients with either ALK-positive or RO
Eintrag öffnenXalkori · 4.8 · Adult patients with NSCLC In studies with crizotinib in adult patients with either ALK-positive or ROS1-positi
Eintrag öffnenXalkori · 4.8 · Adult patients with NSCLC Nausea (57%), diarrhoea (54%), vomiting (51%) and constipation (43%) were the most c
Eintrag öffnenXalkori · 4.8 · Adult patients with NSCLC Severe, life-threatening, or fatal ILD/pneumonitis can occur in patients treated wit
Eintrag öffnenXalkori · 4.8 · Although not all adverse reactions identified in the adult population have been observed in clinical trials of
Eintrag öffnenXalkori · 4.8 · An ophthalmology substudy using specific ophthalmic assessments at specified time points was conducted in 54 a
Eintrag öffnenXalkori · 4.8 · Based on the Visual Symptom Assessment Questionnaire (VSAQ-ALK), adult patients treated with crizotinib in Stu
Eintrag öffnenXalkori · 4.8 · Bradycardia The use of concomitant medicinal products associated with bradycardia should be carefully evaluate
Eintrag öffnenXalkori · 4.8 · Description of selected adverse reactions
Eintrag öffnenXalkori · 4.8 · Gastrointestinal effects Supportive care should include the use of antiemetic medicinal products. For addition
Eintrag öffnenXalkori · 4.8 · Grade 3 and 4 transaminase elevations were generally reversible upon dosing interruption. Across studies with
Eintrag öffnenXalkori · 4.8 · Hepatotoxicity Patients should be monitored for hepatotoxicity and managed as recommended in sections 4.2 and
Eintrag öffnenXalkori · 4.8 · In adult patients with new onset of Grade 4 visual loss, crizotinib treatment should be discontinued and ophth
Eintrag öffnenXalkori · 4.8 · In clinical studies of adult patients with NSCLC treated with crizotinib, events of gastrointestinal perforati
Eintrag öffnenXalkori · 4.8 · In clinical studies of crizotinib in adult patients with either ALK-positive or ROS1-positive advanced NSCLC,
Eintrag öffnenXalkori · 4.8 · In clinical studies with crizotinib, 41 patients with ALK-positive ALCL or ALK-positive IMT, vision disorder h
Eintrag öffnenXalkori · 4.8 · Increases to Grade 3 or 4 ALT or AST elevations were observed in 187 (11%) and 95 (6%) of adult patients, resp
Eintrag öffnenXalkori · 4.8 · Interstitial lung disease/pneumonitis Patients with pulmonary symptoms indicative of ILD/pneumonitis should be
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