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Yuvanci · 4.5 · The safety and efficacy of combinations of tadalafil and other PDE5 inhibitors or other treatments for erectil
Eintrag öffnenYuvanci · 4.5 · Treatments for erectile dysfunction
Eintrag öffnenYuvanci · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenYuvanci · 4.8 Undesirable effects · 1
Eintrag öffnenYuvanci · 4.8 · 10 Ventricular arrhythmiae Not knownf Vascular disorders Flushinga,g Very common Hypotension Common Respirator
Eintrag öffnenYuvanci · 4.8 · 11 In SERAPHIN, a long-term double-blind study of macitentan in patients with PAH, hypotension was reported fo
Eintrag öffnenYuvanci · 4.8 · 12 blind / open-label phase of the study, treatment with Yuvanci was associated with a decrease in mean platel
Eintrag öffnenYuvanci · 4.8 · 9 The safety profile presented below is based on data for Yuvanci and the known safety profile of the individu
Eintrag öffnenYuvanci · 4.8 · Adverse reactions are listed by MedDRA system organ class and by frequency. Frequency categories are defined a
Eintrag öffnenYuvanci · 4.8 · Description of selected adverse reactions
Eintrag öffnenYuvanci · 4.8 · Haemoglobin decreases and anaemia In the double-blind period of the A DUE study with Yuvanci in patients with
Eintrag öffnenYuvanci · 4.8 · Hypotension
Eintrag öffnenYuvanci · 4.8 · Hypotension has been associated with the use of ERAs including macitentan. In the double-blind period of the A
Eintrag öffnenYuvanci · 4.8 · In SERAPHIN, macitentan 10 mg monotherapy was associated with a decrease in mean leucocyte count from baseline
Eintrag öffnenYuvanci · 4.8 · In SERAPHIN, macitentan 10 mg monotherapy was associated with a decrease in mean platelet count from baseline
Eintrag öffnenYuvanci · 4.8 · In SERAPHIN, macitentan 10 mg monotherapy was associated with a mean decrease in haemoglobin of 0.69 mmol/L (1
Eintrag öffnenYuvanci · 4.8 · In SERAPHIN, the incidence of aminotransferase elevations (ALT/AST) > 3 × ULN was 3.4% on macitentan 10 mg mon
Eintrag öffnenYuvanci · 4.8 · In SERAPHIN, the incidence of oedema adverse events in the macitentan 10 mg monotherapy and placebo treatment
Eintrag öffnenYuvanci · 4.8 · Known adverse reactions for macitentan and tadalafil which have not been observed in the A DUE study, are incl
Eintrag öffnenYuvanci · 4.8 · Laboratory abnormalities
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