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18 angezeigte Treffer · Seite 3, keine Gesamtzahl für „Zelboraf“
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Zelboraf · 4.8 · Liver injury (g) Based on the criteria for drug induced liver injury developed by an international expert work
Eintrag öffnenZelboraf · 4.8 · Metabolism and Decreased appetite nutrition disorders Nervous system Headache, 7th nerve disorders dysgeusia,
Eintrag öffnenZelboraf · 4.8 · Musculoskeletal and Arthralgia, Arthritis, Plantar fascial connective tissue myalgia, pain in fibromatosis(1)(
Eintrag öffnenZelboraf · 4.8 · New primary melanoma New primary melanomas have been reported in clinical trials. These cases were managed wit
Eintrag öffnenZelboraf · 4.8 · Non-cutaneous squamous cell carcinoma (non-cuSCC) Cases of non-cuSCC have been reported in patients receiving
Eintrag öffnenZelboraf · 4.8 · Paediatric population The safety of vemurafenib in children and adolescents has not been established. No new s
Eintrag öffnenZelboraf · 4.8 · Potentiation of radiation toxicity(i) Cases reported include recall phenomenon, radiation skin injury, radiati
Eintrag öffnenZelboraf · 4.8 · QT prolongation Analysis of centralised ECG data from an open-label uncontrolled phase II QT sub-study in 132
Eintrag öffnenZelboraf · 4.8 · Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medi
Eintrag öffnenZelboraf · 4.8 · Sarcoidosis (j) Cases of sarcoidosis have been reported in patients treated with vemurafenib, mostly involving
Eintrag öffnenZelboraf · 4.8 · Special populations
Eintrag öffnenZelboraf · 4.8 · Summary of the safety profile The most common adverse drug reactions (ADR) of any grade (> 30%) reported with
Eintrag öffnenZelboraf · 4.8 · System organ class Very Common Common Uncommon Rare
Eintrag öffnenZelboraf · 4.8 · Table 5: Acute kidney injury cases in the phase III study
Eintrag öffnenZelboraf · 4.8 · Tabulated summary of adverse reactions ADRs which were reported in melanoma patients are listed below by MedDR
Eintrag öffnenZelboraf · 4.8 · There were no increases to Grade 4 ALT, alkaline phosphatase or bilirubin.
Eintrag öffnenZelboraf · 4.8 · Vemurafenib (%) Dacarbazine (%) Acute kidney injury cases* 10.0 1.4 Acute kidney injury cases associated with
Eintrag öffnenZelboraf · 4.8 · Vemurafenib (%) Dacarbazine (%) Change 1 grade from baseline to any grade 27.9 6.1 Change 1 grade from bas
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