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Spexotras · 4.8 · Table 5 Adverse reactions with trametinib in combination with dabrafenib
Eintrag öffnenSpexotras · 4.8 · The safety of trametinib in combination with dabrafenib has been evaluated in a pooled safety set of 171 paedi
Eintrag öffnenSpexotras · 4.8 · Visual impairment In paediatric patients treated with trametinib in combination with dabrafenib, ophthalmologi
Eintrag öffnenTafinlar · 4.5 · 13 Effect of food on dabrafenib
Eintrag öffnenTafinlar · 4.5 · Administration of dabrafenib 150 mg twice daily and warfarin resulted in a decrease in AUC of S- and R- warfar
Eintrag öffnenTafinlar · 4.5 · Administration of gemfibrozil (a CYP2C8 inhibitor) 600 mg twice daily, with dabrafenib 75 mg twice daily, resu
Eintrag öffnenTafinlar · 4.5 · Administration of ketoconazole (a CYP3A4 inhibitor) 400 mg once daily, with dabrafenib 75 mg twice daily, resu
Eintrag öffnenTafinlar · 4.5 · Administration of rifampin (a CYP3A4/CYP2C8 inducer) 600 mg once daily, with dabrafenib 150 mg twice daily, re
Eintrag öffnenTafinlar · 4.5 · Co-administration of repeat doses of dabrafenib 150 mg twice daily and the pH-elevating agent rabeprazole 40 m
Eintrag öffnenTafinlar · 4.5 · Co-administration of repeat dosing of trametinib 2 mg once daily and dabrafenib 150 mg twice daily resulted in
Eintrag öffnenTafinlar · 4.5 · Dabrafenib is a substrate for the metabolising enzymes CYP2C8 and CYP3A4, while the active metabolites hydroxy
Eintrag öffnenTafinlar · 4.5 · Dabrafenib is an enzyme inducer and increases the synthesis of drug-metabolising enzymes including CYP3A4, CYP
Eintrag öffnenTafinlar · 4.5 · Dabrafenib is an in vitro inhibitor of human organic anion transporting polypeptide (OATP) 1B1 (OATP1B1), OATP
Eintrag öffnenTafinlar · 4.5 · Effect of dabrafenib on other medicinal products
Eintrag öffnenTafinlar · 4.5 · Effect of other medicinal products on dabrafenib
Eintrag öffnenTafinlar · 4.5 · Effects of dabrafenib on substance transport systems
Eintrag öffnenTafinlar · 4.5 · In vitro, dabrafenib is a mechanism based inhibitor of CYP3A4. Therefore, transient inhibition of CYP3A4 may b
Eintrag öffnenTafinlar · 4.5 · In vitro, dabrafenib produced dose-dependent increases in CYP2B6 and CYP3A4. In a clinical drug interaction st
Eintrag öffnenTafinlar · 4.5 · Onset of induction is likely to occur after 3 days of repeat dosing with dabrafenib. Upon discontinuation of d
Eintrag öffnenTafinlar · 4.5 · Patients should take dabrafenib as monotherapy or in combination with trametinib at least one hour prior to or
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