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Rapamune · 4.5 · Inducers of CYP3A4 may increase the metabolism of sirolimus and decrease sirolimus blood levels (e.g., St. Joh
Eintrag öffnenRapamune · 4.5 · Inhibitors of CYP3A4 may decrease the metabolism of sirolimus and increase sirolimus blood levels. Such inhibi
Eintrag öffnenRapamune · 4.5 · Inhibitors of CYP3A4 may decrease the metabolism of sirolimus and increase sirolimus blood levels. Such inhibi
Eintrag öffnenRapamune · 4.5 · Multiple-dose administration of erythromycin and sirolimus oral solution significantly increased the rate and
Eintrag öffnenRapamune · 4.5 · Multiple-dose administration of erythromycin and sirolimus oral solution significantly increased the rate and
Eintrag öffnenRapamune · 4.5 · Multiple-dose administration of verapamil and sirolimus oral solution significantly affected the rate and exte
Eintrag öffnenRapamune · 4.5 · Multiple-dose administration of verapamil and sirolimus oral solution significantly affected the rate and exte
Eintrag öffnenRapamune · 4.5 · No clinically significant pharmacokinetic interaction was observed between sirolimus and any of the following
Eintrag öffnenRapamune · 4.5 · No clinically significant pharmacokinetic interaction was observed between sirolimus and any of the following
Eintrag öffnenRapamune · 4.5 · Sirolimus is extensively metabolised by the CYP3A4 isozyme in the intestinal wall and liver. Sirolimus is also
Eintrag öffnenRapamune · 4.5 · Sirolimus is extensively metabolised by the CYP3A4 isozyme in the intestinal wall and liver. Sirolimus is also
Eintrag öffnenRapamune · 4.5 · The rate and extent of sirolimus absorption was significantly increased by ciclosporin A (CsA). Sirolimus admi
Eintrag öffnenRapamune · 4.5 · The rate and extent of sirolimus absorption was significantly increased by ciclosporin A (CsA). Sirolimus admi
Eintrag öffnenRapamune · 4.5 · There have been reports of increased blood levels of sirolimus during concomitant use with cannabidiol. Co-adm
Eintrag öffnenRapamune · 4.5 · There have been reports of increased blood levels of sirolimus during concomitant use with cannabidiol. Co-adm
Eintrag öffnenRapamune · 4.8 · 34 In a study evaluating the safety and efficacy of conversion from calcineurin inhibitors to sirolimus (targe
Eintrag öffnenRapamune · 4.8 · Hepatoxicity has been reported. The risk may increase as the trough sirolimus level increases. Rare reports of
Eintrag öffnenRapamune · 4.8 · Hepatoxicity has been reported. The risk may increase as the trough sirolimus level increases. Rare reports of
Eintrag öffnenRapamune · 4.8 · In a study evaluating the safety and efficacy of conversion from calcineurin inhibitors to sirolimus (target l
Eintrag öffnenRapamune · 4.8 · In patients with delayed graft function, sirolimus may delay recovery of renal function.
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