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Tolvaptan Accord · 4.5 · Effect of tolvaptan on the pharmacokinetics of other products
Eintrag öffnenTolvaptan Accord · 4.5 · In addition to its renal aquaretic effect, tolvaptan is capable of blocking vascular vasopressin V2-receptors
Eintrag öffnenTolvaptan Accord · 4.5 · In healthy subjects, tolvaptan, a CYP3A4 substrate, had no effect on the plasma concentrations of some other C
Eintrag öffnenTolvaptan Accord · 4.5 · P-glycoprotein substrates In-vitro studies indicate that tolvaptan is a substrate and competitive inhibitor of
Eintrag öffnenTolvaptan Accord · 4.5 · There is no experience from controlled clinical trials with concomitant use of tolvaptan and other treatments
Eintrag öffnenTolvaptan Accord · 4.5 · Tolvaptan plasma concentrations have been decreased by up to 87 % (AUC) after the administration of CYP3A4 ind
Eintrag öffnenTolvaptan Accord · 4.5 · Tolvaptan plasma concentrations have been increased by up to 5.4-fold area under time-concentration curve (AUC
Eintrag öffnenTolvaptan Accord · 4.5 · Transporter substrates
Eintrag öffnenTolvaptan Accord · 4.5 · While there does not appear to be a synergistic or additive effect of concomitant use of tolvaptan with loop a
Eintrag öffnenTolvaptan Accord · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenTolvaptan Accord · 4.8 Undesirable effects · 1
Eintrag öffnenTolvaptan Accord · 4.8 · 8 System Organ Frequency Class Very common Common Uncommon Not known Skin and Ecchymosis, Pruritic rash1 subcu
Eintrag öffnenTolvaptan Accord · 4.8 · Description of selected adverse reactions
Eintrag öffnenTolvaptan Accord · 4.8 · Hepatobiliary Hepatic disorders2 disorders Acute hepatic failure3 Investigations Blood urine Bilirubin Elevate
Eintrag öffnenTolvaptan Accord · 4.8 · Nervous system Syncope1, Dysgeusia disorders Headache1, Dizziness1
Eintrag öffnenTolvaptan Accord · 4.8 · Rapid correction of hyponatremia In a post-authorisation safety study of tolvaptan in hyponatremia secondary t
Eintrag öffnenTolvaptan Accord · 4.8 · Reporting of suspected adverse reactions
Eintrag öffnenTolvaptan Accord · 4.8 · Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows con
Eintrag öffnenTolvaptan Accord · 4.8 · Summary of the safety profile
Eintrag öffnenTolvaptan Accord · 4.8 · System Organ Frequency Class Very common Common Uncommon Not known Immune system Anaphylactic disorders shock,
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