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Herzuma · 4.8 · It is estimated that approximately 40% of patients who are treated with trastuzumab will experience some form
Eintrag öffnenHerzuma · 4.8 · Severe pulmonary adverse reactions occur in association with the use of trastuzumab and have been associated w
Eintrag öffnenHerzuma · 4.8 · Table 1 Undesirable effects reported with intravenous trastuzumab monotherapy or in combination with chemother
Eintrag öffnenHerzuma · 4.8 · The clinical relevance of these antibodies is not known. The presence of anti-trastuzumab antibodies had no im
Eintrag öffnenHerzuma · 4.8 · There are no immunogenicity data available for trastuzumab in gastric cancer.
Eintrag öffnenHerzuma · 4.8 · When trastuzumab was administered after completion of adjuvant chemotherapy NYHA Class III - IV heart failure
Eintrag öffnenKadcyla · 4.5 · In vitro metabolism studies in human liver microsomes suggest that DM1, a component of trastuzumab emtansine,
Eintrag öffnenKadcyla · 4.8 · 11 Table 3 Tabulated list of ADRs in patients treated with trastuzumab emtansine in clinical studies System Or
Eintrag öffnenKadcyla · 4.8 · Extravasation Reactions secondary to extravasation have been observed in clinical studies with trastuzumab emt
Eintrag öffnenKadcyla · 4.8 · Haemorrhage Haemorrhagic events were reported in 34.8% of patients in MBC clinical studies with trastuzumab em
Eintrag öffnenKadcyla · 4.8 · Immunogenicity As with all therapeutic proteins, there is the potential for an immune response to trastuzumab
Eintrag öffnenKadcyla · 4.8 · Table 4 Laboratory abnormalities observed in patients treated with trastuzumab emtansine in study TDM4370g/BO2
Eintrag öffnenKadcyla · 4.8 · Table 5 Laboratory abnormalities observed in patients treated with trastuzumab emtansine in study BO27938/KATH
Eintrag öffnenKadcyla · 4.8 · Tables 4 and 5 displays laboratory abnormalities observed in patients treated with trastuzumab emtansine in cl
Eintrag öffnenKadcyla · 4.8 · The ADRs in 2 611 patients treated with trastuzumab emtansine are presented in Table 3. The ADRs are listed be
Eintrag öffnenKadcyla · 4.8 · The safety of trastuzumab emtansine has been evaluated in 2 611 breast cancer patients in clinical studies. In
Eintrag öffnenKadcyla · 4.8 · Trastuzumab emtansine (N = 490) All Parameter Grades (%) Grade 3 (%) Grade 4 (%) Hepatic Increased bilirubin 2
Eintrag öffnenKadcyla · 4.8 · Trastuzumab emtansine (N = 740) Parameter All Grade % Grade 3 (%) Grade 4 (%) Hepatic Increased bilirubin 11 0
Eintrag öffnenKanjinti · 4.3 · • Hypersensitivity to trastuzumab, murine proteins, or to any of the excipients listed in section 6.1. • Sever
Eintrag öffnenKanjinti · 4.5 · 9 women with HER2 positive MBC indicates that individual and mean trastuzumab trough serum concentrations vari
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