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Aptivus · 4.5 · Tipranavir: ↔ Valaciclovir: ↔ Alpha 1-adrenoreceptor antagonists Alfuzosin Based on theoretical The concomitan
Eintrag öffnenAptivus · 4.5 · Transient inhibition of P-gp by tipranavir/r, followed by induction of P-gp by tipranavir/r at steady-state
Eintrag öffnenAptivus · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenAptivus · 4.8 Undesirable effects · 1
Eintrag öffnenAptivus · 4.8 · 24 Tabulated summary of adverse reactions associated with Aptivus based on clinical studies and post- marketin
Eintrag öffnenAptivus · 4.8 · 25 co-infection with hepatitis B or C were risk factors for these elevations. Most patients were able to conti
Eintrag öffnenAptivus · 4.8 · 26 Paediatric population In an open-label, dose-finding study of tipranavir plus ritonavir (Trial 1182.14), 28
Eintrag öffnenAptivus · 4.8 · Aptivus co-administered with low dose ritonavir, has been associated with reports of significant liver toxicit
Eintrag öffnenAptivus · 4.8 · Bleeding This adverse reaction was identified through post-marketing surveillance but not observed in randomis
Eintrag öffnenAptivus · 4.8 · Blood and lymphatic system disorders uncommon neutropenia, anaemia, thrombocytopenia Immune system disorders u
Eintrag öffnenAptivus · 4.8 · Cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors,
Eintrag öffnenAptivus · 4.8 · Description of selected adverse reactions The following clinical safety features (hepatotoxicity, hyperlipidae
Eintrag öffnenAptivus · 4.8 · Hepatotoxicity After 48 weeks of follow-up, the frequency of Grade 3 or 4 ALAT and/or ASAT abnormalities was h
Eintrag öffnenAptivus · 4.8 · Hyperlipidaemia Grade 3 or 4 elevations of triglycerides occurred more frequently in the tipranavir with riton
Eintrag öffnenAptivus · 4.8 · In HIV-infected patients with severe immune deficiency at the time of initiation of combination antiretroviral
Eintrag öffnenAptivus · 4.8 · Increased CPK, myalgia, myositis and, rarely, rhabdomyolysis, have been reported with protease inhibitors, par
Eintrag öffnenAptivus · 4.8 · Laboratory abnormalities Frequencies of marked clinical laboratory abnormalities (Grade 3 or 4) reported in at
Eintrag öffnenAptivus · 4.8 · Limited data are currently available for the use of Aptivus, co-administered with low dose ritonavir, in patie
Eintrag öffnenAptivus · 4.8 · Metabolic parameters Weight and levels of blood lipids and glucose may increase during antiretroviral therapy
Eintrag öffnenAptivus · 4.8 · Most frequently reported moderate or severe adverse reactions in paediatric patients aged 12 to 18 years who t
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