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Retsevmo · 4.8 · 17 (37.5%), than in patients <65 years of age (7.6%). In study LIBRETTO-431, the frequency of AE leading to di
Eintrag öffnenRetsevmo · 4.8 · 45 MedDRA system MedDRA preferred term Frequency of all Frequency of Grade organ class Grades ≥3 Gastrointesti
Eintrag öffnenRetsevmo · 4.8 · 46 h Hypertension includes hypertension and blood pressure increased. i Haemorrhage includes epistaxis, haemop
Eintrag öffnenRetsevmo · 4.8 · 47 Dose modification is recommended for patients who develop Grade 3 or 4 ALT or AST increase (see section 4.2
Eintrag öffnenRetsevmo · 4.8 · 48 In LIBRETTO-001, the median time to onset was 1.9 weeks (range: 0.7 to 203.9 weeks): 1.7 weeks in patients
Eintrag öffnenRetsevmo · 4.8 · 49 MedDRA system MedDRA preferred Frequency of all Frequency of Grade ≥ 3 organ class term Grades# Immune syst
Eintrag öffnenRetsevmo · 4.8 · Additional information on special populations
Eintrag öffnenRetsevmo · 4.8 · Additional information on special populations
Eintrag öffnenRetsevmo · 4.8 · Aminotransferase elevations (AST / ALT increased) Based on laboratory assessment, ALT and AST elevations were
Eintrag öffnenRetsevmo · 4.8 · Aminotransferase elevations (AST / ALT increased) Based on laboratory assessment, ALT and AST elevations were
Eintrag öffnenRetsevmo · 4.8 · Description of selected adverse reactions in patients receiving selpercatinib
Eintrag öffnenRetsevmo · 4.8 · Description of selected adverse reactions in patients receiving selpercatinib
Eintrag öffnenRetsevmo · 4.8 · Elderly In patients receiving selpercatinib, 24.7% were ≥65-74 years of age, 8.6% were 75-84 years of age, and
Eintrag öffnenRetsevmo · 4.8 · Elderly In patients receiving selpercatinib, 24.7% were ≥65-74 years of age, 8.6% were 75-84 years of age, and
Eintrag öffnenRetsevmo · 4.8 · Haemorrhages Grade ≥3 haemorrhagic events occurred in 2.5% of patients treated with selpercatinib across studi
Eintrag öffnenRetsevmo · 4.8 · Haemorrhages Grade ≥3 haemorrhagic events occurred in 2.5% of patients treated with selpercatinib across studi
Eintrag öffnenRetsevmo · 4.8 · Hypersensitivity Signs and symptoms of hypersensitivity included fever, rash and arthralgias or myalgias with
Eintrag öffnenRetsevmo · 4.8 · Hypersensitivity Signs and symptoms of hypersensitivity included fever, rash and arthralgias or myalgias with
Eintrag öffnenRetsevmo · 4.8 · Hypertension In the 837 patients who had blood pressure measurements in study LIBRETTO-001, the median maximum
Eintrag öffnenRetsevmo · 4.8 · Hypertension In the 837 patients who had blood pressure measurements in study LIBRETTO-001, the median maximum
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