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Clopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · 7 Less pronounced reductions of metabolite exposure has been observed with pantoprazole or lansoprazole. The p
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · 8 Rosuvastatin Clopidogrel has been shown to increase rosuvastatin exposure in patients by 2-fold (AUC) and 1.
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · A significantly reduced platelet inhibition has been shown in HIV patients treated with ritonavir-or cobicista
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Acetylsalicylic acid (ASA) ASA did not modify the clopidogrel-mediated inhibition of ADP-induced platelet aggr
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Apart from the specific medicinal product interaction information described above, interaction studies with cl
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · As with other oral P2Y12 inhibitors, co-administration of opioid agonists has the potential to delay and reduc
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Boosted anti-retroviral therapy (ART) HIV patients treated with boosted anti-retroviral therapies (ART) are at
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · CYP2C8 substrate medicinal products Clopidogrel has been shown to increase repaglinide exposure in healthy vol
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Data from the CAPRIE study indicate that phenytoin and tolbutamide which are metabolised by CYP2C9 can be safe
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Glycoprotein IIb/IIIa inhibitors Clopidogrel should be used with caution in patients who receive concomitant g
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Inconsistent data on the clinical implications of this pharmacokinetic (PK)/pharmacodynamic (PD) interaction i
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Inhibitors of CYP2C19 Since clopidogrel is metabolised to its active metabolite partly by CYP2C19, use of medi
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Medicinal products associated with bleeding risk There is an increased risk of bleeding due to the potential a
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Medicinal products that are strong or moderate CYP2C19 inhibitors include, for example, omeprazole and esomepr
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · NSAIDs In a clinical study conducted in healthy volunteers, the concomitant administration of clopidogrel and
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Oral anticoagulants The concomitant administration of clopidogrel with oral anticoagulants is not recommended
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Other concomitant therapy Inducers of CYP2C19 Since clopidogrel is metabolised to its active metabolite partly
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Other medicinal products A number of other clinical studies have been conducted with clopidogrel and other con
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Proton Pump Inhibitors (PPI) Omeprazole 80 mg once daily administered either at the same time as clopidogrel o
Eintrag öffnenClopidogrel Zentiva (previously Clopidogrel Winthrop) · 4.5 · Rifampicin strongly induces CYP2C19, resulting in both an increased level of clopidogrel active metabolite and
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