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Tafinlar · 4.5 · Potentiation of radiation treatment toxicity has been reported in patients receiving dabrafenib as monotherapy
Eintrag öffnenTafinlar · 4.5 · When dabrafenib is used in combination with trametinib refer to the guidance for medicinal product interaction
Eintrag öffnenTafinlar · 4.8 · 19 Pancreatitis Pancreatitis has been reported in dabrafenib monotherapy and in combination with trametinib. U
Eintrag öffnenTafinlar · 4.8 · Adverse reactions associated with dabrafenib obtained from clinical studies and post-marketing surveillance ar
Eintrag öffnenTafinlar · 4.8 · Arthralgia Arthralgia was reported very commonly in the integrated safety population of dabrafenib monotherapy
Eintrag öffnenTafinlar · 4.8 · Cutaneous squamous cell carcinoma For dabrafenib monotherapy in study MEK115306, cutaneous squamous cell carci
Eintrag öffnenTafinlar · 4.8 · Dabrafenib in combination with trametinib in patients with brain metastases
Eintrag öffnenTafinlar · 4.8 · Elderly Of the total number of patients in the integrated safety population of dabrafenib monotherapy (n=578),
Eintrag öffnenTafinlar · 4.8 · Hepatic events Hepatic adverse events have been reported in clinical studies with dabrafenib in combination wi
Eintrag öffnenTafinlar · 4.8 · Hypertension Elevations in blood pressure have been reported in association with dabrafenib in combination wit
Eintrag öffnenTafinlar · 4.8 · In clinical studies in other indications, the safety profile of dabrafenib in combination with trametinib in p
Eintrag öffnenTafinlar · 4.8 · In the integrated safety population of dabrafenib in combination with trametinib (n=1 188), 27% of patients we
Eintrag öffnenTafinlar · 4.8 · New primary melanoma New primary melanomas have been reported in clinical studies with dabrafenib as monothera
Eintrag öffnenTafinlar · 4.8 · Pyrexia Fever has been reported in clinical studies with dabrafenib as monotherapy and in combination with tra
Eintrag öffnenTafinlar · 4.8 · Table 3 Adverse reactions with dabrafenib monotherapy
Eintrag öffnenTafinlar · 4.8 · Table 4 Adverse reactions with dabrafenib in combination with trametinib
Eintrag öffnenTafinlar · 4.8 · The most common adverse reactions (incidence ≥20%) for dabrafenib in combination with trametinib were: pyrexia
Eintrag öffnenTafinlar · 4.8 · The safety and efficacy of the combination of dabrafenib and trametinib have been evaluated in a multi-cohort,
Eintrag öffnenTafinlar · 4.8 · The safety of dabrafenib capsules has not been evaluated in prospective clinical studies of adolescent patient
Eintrag öffnenTafinlar · 4.8 · The safety of dabrafenib in combination with trametinib has been evaluated in the integrated safety population
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