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Votubia · 4.5 · CYP3A4 and PgP inhibitors increasing everolimus concentrations
Eintrag öffnenVotubia · 4.5 · Everolimus is a substrate of CYP3A4, and also a substrate and moderate inhibitor of PgP. Therefore, absorption
Eintrag öffnenVotubia · 4.5 · Everolimus is a substrate of CYP3A4, and also a substrate and moderate inhibitor of PgP. Therefore, absorption
Eintrag öffnenVotubia · 4.5 · For patients not receiving concomitant strong inducers at the start of everolimus treatment, the co-administra
Eintrag öffnenVotubia · 4.5 · In EXIST-3 (Study CRAD001M2304), everolimus increased pre-dose concentrations of the antiepileptics carbamazep
Eintrag öffnenVotubia · 4.5 · In EXIST-3 (Study CRAD001M2304), everolimus increased pre-dose concentrations of the antiepileptics carbamazep
Eintrag öffnenVotubia · 4.5 · Potentiation of radiation treatment toxicity has been reported in patients receiving everolimus (see sections
Eintrag öffnenVotubia · 4.5 · Potentiation of radiation treatment toxicity has been reported in patients receiving everolimus (see sections
Eintrag öffnenVotubia · 4.5 · Substances that are inducers of CYP3A4 or PgP may decrease everolimus blood concentrations by increasing metab
Eintrag öffnenVotubia · 4.5 · Substances that are inducers of CYP3A4 or PgP may decrease everolimus blood concentrations by increasing metab
Eintrag öffnenVotubia · 4.5 · Substances that are inhibitors of CYP3A4 or PgP may increase everolimus blood concentrations by decreasing met
Eintrag öffnenVotubia · 4.5 · Substances that are inhibitors of CYP3A4 or PgP may increase everolimus blood concentrations by decreasing met
Eintrag öffnenVotubia · 4.5 · Table 3 Effects of other active substances on everolimus
Eintrag öffnenVotubia · 4.8 · 41 • EXIST-2 (CRAD001M2302): This was a randomised, double-blind, controlled, phase III trial of everolimus (n
Eintrag öffnenVotubia · 4.8 · 43 In clinical studies and post-marketing spontaneous reports, everolimus has been associated with cases of pn
Eintrag öffnenVotubia · 4.8 · In clinical studies and post-marketing spontaneous reports, everolimus has been associated with cases of pneum
Eintrag öffnenVotubia · 4.8 · In clinical studies and post-marketing spontaneous reports, everolimus has been associated with renal failure
Eintrag öffnenVotubia · 4.8 · In clinical studies and post-marketing spontaneous reports, everolimus has been associated with renal failure
Eintrag öffnenVotubia · 4.8 · In clinical studies, everolimus has been associated with haemorrhage events. On rare occasions, fatal outcomes
Eintrag öffnenVotubia · 4.8 · In clinical studies, everolimus has been associated with haemorrhage events. On rare occasions, fatal outcomes
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