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Begriffe & Kennungen
Clopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · 6 Other concomitant therapy with clopidogrel Since clopidogrel is metabolised to its active metabolite partly
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · 7 Caution is required because ASA may inhibit the effect of uricosuric agents through competitive elimination
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Acetazolamide Caution is recommended when co-administering salicylates with acetazolamide as there is an incre
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Alcohol Alcohol may increase the risk of gastrointestinal injury when taken with ASA. Patients should be couns
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Apart from the specific medicinal product interaction information described above, interaction studies with Cl
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · As with other oral P2Y12 inhibitors, co-administration of opioid agonists has the potential to delay and reduc
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · CYP2C8 substrate medicinal products: Clopidogrel has been shown to increase repaglinide exposure in healthy vo
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Data from the CAPRIE study indicate that phenytoin and tolbutamide which are metabolised by CYP2C9 can be safe
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on platelet aggregation wh
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Glycoprotein IIb/IIIa inhibitors Clopidogrel/Acetylsalicylic acid Zentiva should be used with caution in patie
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Heparin In a clinical study conducted in healthy subjects, clopidogrel did not necessitate modification of the
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Inconsistent data on the clinical implications of this pharmacokinetic (PK)/pharmacodynamic (PD) interaction i
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Less pronounced reductions of metabolite exposure has been observed with pantoprazole or lansoprazole. The pla
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Medicinal products associated with bleeding risk There is an increased risk of bleeding due to the potential a
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Medicinal products that are strong or moderate CYP2C19 inhibitors include, for example, omeprazole and esomepr
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Metamizole Metamizole may reduce the effect of ASA on platelet aggregation when taken concomitantly. Therefore
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Methotrexate Due to the presence of ASA, methotrexate used at doses higher than 20 mg/week should be used with
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · NSAIDs In a clinical study conducted in healthy volunteers, the concomitant administration of clopidogrel and
Eintrag öffnenClopidogrel/Acetylsalicylic acid Zentiva (previously DuoCover) · 4.5 · Nicorandil In patients concomitantly receiving nicorandil and NSAIDs including ASA and LAS, there is an increa
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