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Enyglid · 4.5 · Co-administration of cimetidine, nifedipine, oestrogen, or simvastatin with repaglinide, all CYP3A4 substrates
Eintrag öffnenEnzalutamide Viatris · 4.5 · BCRP substrates At steady-state, enzalutamide did not cause a clinically meaningful change in exposure to the
Eintrag öffnenEnzalutamide Viatris · 4.5 · CYP1A2 and CYP2C8 substrates Enzalutamide (160 mg once daily) did not cause a clinically relevant change in th
Eintrag öffnenEnzalutamide Viatris · 4.5 · MRP2, OAT3 and OCT1 substrates Based on in vitro data, inhibition of MRP2 (in the intestine), as well as organ
Eintrag öffnenEnzalutamide Viatris · 4.5 · P-gp substrates In vitro data indicate that enzalutamide may be an inhibitor of the efflux transporter P-gp. A
Eintrag öffnenEpclusa · 4.5 · Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP. Velpatasvir is also a substrate
Eintrag öffnenEpclusa · 4.5 · Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP. Velpatasvir is also a substrate
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2B6 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of bupr
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2C19 substrates In vitro data have demonstrated that cannabidiol inhibits CYP2C19, which may caus
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2C8 substrates Because of potential inhibition of enzyme activity, dose reduction of substrates o
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2C9 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of tolb
Eintrag öffnenEpidyolex · 4.5 · Sensitive P-gp substrates given orally Coadministration of cannabidiol with orally administered everolimus, a
Eintrag öffnenEpidyolex · 4.5 · Sensitive UGT1A9 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of myco
Eintrag öffnenEpidyolex · 4.5 · Sensitive UGT2B7 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of zido
Eintrag öffnenEpidyolex · 4.5 · Sensitive substrates of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, UGT1A9, and UGT2B7 Sensitive CYP1A2 substrate
Eintrag öffnenErivedge · 4.5 · Clinically significant PK interactions between vismodegib and CYP450 substrates are not expected. In vitro, CY
Eintrag öffnenEtcamah · 4.5 · 6 be avoided. All other CYP2B6 substrates are permitted but caution should be exercised and patients monitored
Eintrag öffnenEtcamah · 4.5 · BCRP sensitive substrates In vitro data show that camizestrant is an inhibitor of Breast Cancer Resistance Pro
Eintrag öffnenEtcamah · 4.5 · CYP2B6 sensitive substrates In vitro data show that camizestrant is an inhibitor of Cytochrome P450 2B6 (CYP2B
Eintrag öffnenEtcamah · 4.5 · CYP2C9 and CYP2C19 substrates In vitro data in conjunction with mechanistic static modelling show that camizes
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