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Aptivus · 4.3 · 3 Combination of rifampicin with Aptivus with concomitant low dose ritonavir is contraindicated (see section 4
Eintrag öffnenAptivus · 4.3 · Co-administration of Aptivus with low dose ritonavir, with active substances that are highly dependent on CYP3
Eintrag öffnenAptivus · 4.5 · 12 Dolutegravir 50 mg QD Dolutegravir ↓ The recommended adult dose of AUC ↓ 59% dolutegravir is 50 mg twice da
Eintrag öffnenAptivus · 4.5 · 17 Tadalafil 10 mg QD Tadalafil first-dose Cmax ↓ 22% It is recommended to prescribe Tadalafil first-dose AUC
Eintrag öffnenAptivus · 4.5 · 18 Antithrombotics Warfarin 10 mg QD First-dose tipranavir/r: Aptivus, co-administered with S-warfarin Cmax ↔
Eintrag öffnenAptivus · 4.5 · Digoxin 0.25 mg QD po First-dose tipranavir/r Digoxin Cmax ↑ 93% Digoxin AUC ↑ 91%
Eintrag öffnenAptivus · 4.5 · Inhibition of CYP 2D6 by tipranavir/r Digoxin 0.25 mg QD iv First-dose tipranavir/r Monitoring of digoxin seru
Eintrag öffnenAptivus · 4.5 · It is difficult to predict the net effect of Aptivus co-administered with low dose ritonavir on oral bioavaila
Eintrag öffnenAptivus · 4.5 · The interaction profile of Aptivus, co-administered with low dose ritonavir, is complex and requires special a
Eintrag öffnenAptivus · 4.8 · 26 Paediatric population In an open-label, dose-finding study of tipranavir plus ritonavir (Trial 1182.14), 28
Eintrag öffnenAptivus · 4.8 · Aptivus co-administered with low dose ritonavir, has been associated with reports of significant liver toxicit
Eintrag öffnenAptivus · 4.8 · Limited data are currently available for the use of Aptivus, co-administered with low dose ritonavir, in patie
Eintrag öffnenAptivus · 4.8 · Rash An interaction study in women between tipranavir, co-administered with low dose ritonavir, and ethinyl oe
Eintrag öffnenAquipta · 4.8 · In 12-week, placebo-controlled prophylaxis clinical studies, 678 patients received at least one dose of atogep
Eintrag öffnenAquipta · 4.8 · Safety was evaluated in 3 852 patients with migraine who received at least one dose of atogepant in clinical s
Eintrag öffnenArava · 4.5 · Effect on caffeine (CYP1A2 substrate) Repeated doses of A771726 decreased mean Cmax and AUC of caffeine (CYP1A
Eintrag öffnenArava · 4.5 · Effect on caffeine (CYP1A2 substrate) Repeated doses of A771726 decreased mean Cmax and AUC of caffeine (CYP1A
Eintrag öffnenArava · 4.5 · Effect on caffeine (CYP1A2 substrate) Repeated doses of A771726 decreased mean Cmax and AUC of caffeine (CYP1A
Eintrag öffnenArava · 4.5 · Effect on warfarin (CYP2C9 substrate) Repeated doses of A771726 had no effect on the pharmacokinetics of S-war
Eintrag öffnenArava · 4.5 · Effect on warfarin (CYP2C9 substrate) Repeated doses of A771726 had no effect on the pharmacokinetics of S-war
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